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• W2084481033 abstract "Phosholamban (PLN) is involved in the contractility of cardiac muscles by regulating the intracellular calcium concentration (Ca(2+)(cyt)) of cardiac myocytes. This occurs via a modulation of the sarco-/endoplasmic CaATPase (SERCA). In spite of high-resolution structures the molecular mode of PLN action is yet not known. In the present paper we readdress the question whether PLN proteins can generate ion channel activity. Reconstitution of PLN in planar lipid bilayers reveals single channel fluctuations, which are characterized by two conductance levels, long open/closed dwell times, moderate selectivity between monovalent cations and no perceivable Ca(2+) permeability. The PLN generated channel activity could be inhibited by a PLN antibody (abPLN) implying that the channel activity is indeed due to the inherent channel function of the PLN protein." @default.
• W2084481033 created "2016-06-24" @default.
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• W2084481033 date "2011-01-01" @default.
• W2084481033 modified "2023-09-30" @default.
• W2084481033 title "Phospholamban generates cation selective ion channels" @default.
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• W2084481033 doi "https://doi.org/10.1039/c1cp20460b" @default.
• W2084481033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21687864" @default.
• W2084481033 hasPublicationYear "2011" @default.
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