FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084502489> ?p ?o ?g. }

• W2084502489 endingPage "6222" @default.
• W2084502489 startingPage "6215" @default.
• W2084502489 abstract "ABSTRACT Bacteria encounter numerous environmental stresses which can delay or inhibit their growth. Many bacteria utilize alternative σ factors to regulate subsets of genes required to overcome different extracellular assaults. The largest group of these alternative σ factors are the extracytoplasmic function (ECF) σ factors. In this paper, we demonstrate that the expression of the ECF σ factor σ V in Bacillus subtilis is induced specifically by lysozyme but not other cell wall-damaging agents. A mutation in sigV results in increased sensitivity to lysozyme killing, suggesting that σ V is required for lysozyme resistance. Using reverse transcription (RT)-PCR, we show that the previously uncharacterized gene yrhL (here referred to as oatA for O -acetyltransferase) is in a four-gene operon which includes sigV and rsiV . In quantitative RT-PCR experiments, the expression of oatA is induced by lysozyme stress. Lysozyme induction of oatA is dependent upon σ V . Overexpression of oatA in a sigV mutant restores lysozyme resistance to wild-type levels. This suggests that OatA is required for σ V -dependent resistance to lysozyme. We also tested the ability of lysozyme to induce the other ECF σ factors and found that only the expression of sigV is lysozyme inducible. However, we found that the other ECF σ factors contributed to lysozyme resistance. We found that sigX and sigM mutations alone had very little effect on lysozyme resistance but when combined with a sigV mutation resulted in significantly greater lysozyme sensitivity than the sigV mutation alone. This suggests that sigV , sigX , and sigM may act synergistically to control lysozyme resistance. In addition, we show that two ECF σ factor-regulated genes, dltA and pbpX , are required for lysozyme resistance. Thus, we have identified three independent mechanisms which B. subtilis utilizes to avoid killing by lysozyme." @default.
• W2084502489 created "2016-06-24" @default.
• W2084502489 creator A5005514036 @default.
• W2084502489 creator A5043121072 @default.
• W2084502489 creator A5053177002 @default.
• W2084502489 creator A5083877514 @default.
• W2084502489 date "2011-11-15" @default.
• W2084502489 modified "2023-09-23" @default.
• W2084502489 title "The Bacillus subtilis Extracytoplasmic Function σ Factor σ ^V Is Induced by Lysozyme and Provides Resistance to Lysozyme" @default.
• W2084502489 cites W1481446803 @default.
• W2084502489 cites W1527050015 @default.
• W2084502489 cites W1600543875 @default.
• W2084502489 cites W1738392205 @default.
• W2084502489 cites W1897150796 @default.
• W2084502489 cites W1909878702 @default.
• W2084502489 cites W1968718809 @default.
• W2084502489 cites W1987006179 @default.
• W2084502489 cites W1989823376 @default.
• W2084502489 cites W1991302898 @default.
• W2084502489 cites W1992216729 @default.
• W2084502489 cites W2005563340 @default.
• W2084502489 cites W2009182265 @default.
• W2084502489 cites W2014275320 @default.
• W2084502489 cites W2019275072 @default.
• W2084502489 cites W2020340840 @default.
• W2084502489 cites W2030716585 @default.
• W2084502489 cites W2031801904 @default.
• W2084502489 cites W2034159958 @default.
• W2084502489 cites W2044521292 @default.
• W2084502489 cites W2046767419 @default.
• W2084502489 cites W2070756319 @default.
• W2084502489 cites W2087889125 @default.
• W2084502489 cites W2089811840 @default.
• W2084502489 cites W2098570486 @default.
• W2084502489 cites W2104159811 @default.
• W2084502489 cites W2106645024 @default.
• W2084502489 cites W2112580008 @default.
• W2084502489 cites W2114878533 @default.
• W2084502489 cites W2114910711 @default.
• W2084502489 cites W2115119618 @default.
• W2084502489 cites W2116056037 @default.
• W2084502489 cites W2122862073 @default.
• W2084502489 cites W2124513219 @default.
• W2084502489 cites W2125836647 @default.
• W2084502489 cites W2127597865 @default.
• W2084502489 cites W2129281474 @default.
• W2084502489 cites W2131064330 @default.
• W2084502489 cites W2133174811 @default.
• W2084502489 cites W2138307025 @default.
• W2084502489 cites W2144383602 @default.
• W2084502489 cites W2150825041 @default.
• W2084502489 cites W2156143722 @default.
• W2084502489 cites W2156266252 @default.
• W2084502489 cites W2158447179 @default.
• W2084502489 cites W2163773962 @default.
• W2084502489 cites W2168020930 @default.
• W2084502489 cites W2171763199 @default.
• W2084502489 doi "https://doi.org/10.1128/jb.05467-11" @default.
• W2084502489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3209206" @default.
• W2084502489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21856855" @default.
• W2084502489 hasPublicationYear "2011" @default.
• W2084502489 type Work @default.
• W2084502489 sameAs 2084502489 @default.
• W2084502489 citedByCount "66" @default.
• W2084502489 countsByYear W20845024892012 @default.
• W2084502489 countsByYear W20845024892013 @default.
• W2084502489 countsByYear W20845024892014 @default.
• W2084502489 countsByYear W20845024892016 @default.
• W2084502489 countsByYear W20845024892017 @default.
• W2084502489 countsByYear W20845024892018 @default.
• W2084502489 countsByYear W20845024892019 @default.
• W2084502489 countsByYear W20845024892020 @default.
• W2084502489 countsByYear W20845024892021 @default.
• W2084502489 countsByYear W20845024892022 @default.
• W2084502489 countsByYear W20845024892023 @default.
• W2084502489 crossrefType "journal-article" @default.
• W2084502489 hasAuthorship W2084502489A5005514036 @default.
• W2084502489 hasAuthorship W2084502489A5043121072 @default.
• W2084502489 hasAuthorship W2084502489A5053177002 @default.
• W2084502489 hasAuthorship W2084502489A5083877514 @default.
• W2084502489 hasBestOaLocation W20845024891 @default.
• W2084502489 hasConcept C104317684 @default.
• W2084502489 hasConcept C143065580 @default.
• W2084502489 hasConcept C153911025 @default.
• W2084502489 hasConcept C203075996 @default.
• W2084502489 hasConcept C2776966407 @default.
• W2084502489 hasConcept C2777272437 @default.
• W2084502489 hasConcept C28406088 @default.
• W2084502489 hasConcept C523546767 @default.
• W2084502489 hasConcept C54355233 @default.
• W2084502489 hasConcept C547475151 @default.
• W2084502489 hasConcept C55493867 @default.
• W2084502489 hasConcept C86803240 @default.
• W2084502489 hasConcept C89423630 @default.
• W2084502489 hasConceptScore W2084502489C104317684 @default.
• W2084502489 hasConceptScore W2084502489C143065580 @default.
• W2084502489 hasConceptScore W2084502489C153911025 @default.
• W2084502489 hasConceptScore W2084502489C203075996 @default.

• next