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• W2084503313 abstract "Orexin-A (hypocretin-1), a neuropeptide produced in hypothalamus, stimulates arousal. We studied plasma concentrations of orexin-A-like immunoreactivity (orexin-A-LI) in 156 patients with sleep apnea hypopnea syndrome (SAHS) and 22 control subjects. Plasma orexin-A-LI levels were significantly decreased in 156 patients with SAHS (4.4+/-0.15 pmol/l, mean+/-S.E.) as compared with controls (5.3+/-0.45 pmol/l). The levels were decreased in parallel with the severity of sleep-related respiratory disturbance and magnitude of sleep fragmentation. These findings raise the possibility that a low plasma level of orexin-A-LI may be a marker to show the severity of the disease in patients with SAHS." @default.
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• W2084503313 date "2003-03-01" @default.
• W2084503313 modified "2023-09-25" @default.
• W2084503313 title "Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome" @default.
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• W2084503313 doi "https://doi.org/10.1016/s0196-9781(03)00055-x" @default.
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