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- W2084517148 abstract "We studied the effect an alkali-metal ion exercised on the rate of entry of another alkali-metal ion into frog sartorius muscle cells and their models (i.e., ion exchange resin and sheep's wool). In the case of frog muscle, it was shown that the interaction fell into one of four categories; competition, facilitation, and two types of indifference. The observed pK value (4.6 to 4.7) of the surface anionic groups that combine with the alkali-metal ions suggests that they are beta- or gamma-carboxyl groups of proteins on the cell surface. The results were compared with four theoretical models which included three membrane models (continuous lipoid membrane with carrier; leaky membrane with carrier; membrane with fixed ionic sites) and one bulk-phase model. This comparison led to the conclusion that the only model that is self-consistent and agrees with all of the experimental facts is the one based on the concept that the entire living cell represents a proteinaceous fixed-charge system; this model correctly predicts all four types of interaction observed." @default.
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- W2084517148 date "1965-11-01" @default.
- W2084517148 modified "2023-09-27" @default.
- W2084517148 title "Studies on the Ionic Permeability of Muscle Cells and their Models" @default.
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- W2084517148 doi "https://doi.org/10.1016/s0006-3495(65)86752-2" @default.
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