Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084534701> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2084534701 endingPage "1434" @default.
- W2084534701 startingPage "1433" @default.
- W2084534701 abstract "We thank Singh et al. for their thoughtful letter.1 This highlights three aspects of our manuscript that we believe deserve further discussion.2 First, although we agree that inclusion of vedolizumab, an anti-integrin therapeutic, is a potential option, we elected to focus on comparing anti-tumour necrosis factor (anti-TNF) agents to limit issues of clinical and biologic heterogeneity. Second, we found the definitions and reporting of prior anti-TNF exposure to be inconsistent between studies (e.g. prior anti-TNF permitted but data not reported, variable washout lengths). While we documented reported anti-TNF exposure in Table 1, we were unable to meaningfully analyse patients by prior anti-TNF exposure. Finally, the authors raise concerns over using a clinical endpoint (Mayo score or ulcerative colitis symptom score) as the primary outcome measure in our meta-analysis. Although we agree that objective measures are preferred, the clinical trials available for inclusion in our network meta-analysis were designed and powered based on clinical activity indices. The results of Singh et al.'s work reported similar findings to our analysis – that available clinical trial data do not demonstrate significant differences in efficacy between anti-TNF agents, and potentially vedolizumab. This discussion points out important limitations of the available data, highlighting the need for objective and reproducible measures of disease activity in ulcerative colitis clinical trials. Head-to-head studies are needed to better understand the comparative efficacy of therapies for ulcerative colitis. The authors' declarations of personal and financial interests are unchanged from those in the original article.2" @default.
- W2084534701 created "2016-06-24" @default.
- W2084534701 creator A5008519932 @default.
- W2084534701 creator A5014214683 @default.
- W2084534701 creator A5034549343 @default.
- W2084534701 creator A5038070457 @default.
- W2084534701 creator A5038079014 @default.
- W2084534701 creator A5049202733 @default.
- W2084534701 creator A5051721587 @default.
- W2084534701 creator A5058482449 @default.
- W2084534701 creator A5068100543 @default.
- W2084534701 creator A5084462006 @default.
- W2084534701 date "2014-05-21" @default.
- W2084534701 modified "2023-09-28" @default.
- W2084534701 title "Letter: comparative efficacy of biological therapy in patients with ulcerative colitis - authors’ reply" @default.
- W2084534701 cites W2010007856 @default.
- W2084534701 cites W2039124214 @default.
- W2084534701 cites W2133531206 @default.
- W2084534701 cites W2156950379 @default.
- W2084534701 cites W2162805528 @default.
- W2084534701 cites W2328126238 @default.
- W2084534701 doi "https://doi.org/10.1111/apt.12773" @default.
- W2084534701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24849156" @default.
- W2084534701 hasPublicationYear "2014" @default.
- W2084534701 type Work @default.
- W2084534701 sameAs 2084534701 @default.
- W2084534701 citedByCount "0" @default.
- W2084534701 crossrefType "journal-article" @default.
- W2084534701 hasAuthorship W2084534701A5008519932 @default.
- W2084534701 hasAuthorship W2084534701A5014214683 @default.
- W2084534701 hasAuthorship W2084534701A5034549343 @default.
- W2084534701 hasAuthorship W2084534701A5038070457 @default.
- W2084534701 hasAuthorship W2084534701A5038079014 @default.
- W2084534701 hasAuthorship W2084534701A5049202733 @default.
- W2084534701 hasAuthorship W2084534701A5051721587 @default.
- W2084534701 hasAuthorship W2084534701A5058482449 @default.
- W2084534701 hasAuthorship W2084534701A5068100543 @default.
- W2084534701 hasAuthorship W2084534701A5084462006 @default.
- W2084534701 hasBestOaLocation W20845347011 @default.
- W2084534701 hasConcept C126322002 @default.
- W2084534701 hasConcept C203092338 @default.
- W2084534701 hasConcept C2776207728 @default.
- W2084534701 hasConcept C2779134260 @default.
- W2084534701 hasConcept C2780479503 @default.
- W2084534701 hasConcept C535046627 @default.
- W2084534701 hasConcept C71924100 @default.
- W2084534701 hasConceptScore W2084534701C126322002 @default.
- W2084534701 hasConceptScore W2084534701C203092338 @default.
- W2084534701 hasConceptScore W2084534701C2776207728 @default.
- W2084534701 hasConceptScore W2084534701C2779134260 @default.
- W2084534701 hasConceptScore W2084534701C2780479503 @default.
- W2084534701 hasConceptScore W2084534701C535046627 @default.
- W2084534701 hasConceptScore W2084534701C71924100 @default.
- W2084534701 hasIssue "12" @default.
- W2084534701 hasLocation W20845347011 @default.
- W2084534701 hasLocation W20845347012 @default.
- W2084534701 hasLocation W20845347013 @default.
- W2084534701 hasOpenAccess W2084534701 @default.
- W2084534701 hasPrimaryLocation W20845347011 @default.
- W2084534701 hasRelatedWork W2160475077 @default.
- W2084534701 hasRelatedWork W2332480471 @default.
- W2084534701 hasRelatedWork W2393924593 @default.
- W2084534701 hasRelatedWork W2529617706 @default.
- W2084534701 hasRelatedWork W2765379856 @default.
- W2084534701 hasRelatedWork W2978000335 @default.
- W2084534701 hasRelatedWork W3190671671 @default.
- W2084534701 hasRelatedWork W4318579187 @default.
- W2084534701 hasRelatedWork W4318777090 @default.
- W2084534701 hasRelatedWork W4368368248 @default.
- W2084534701 hasVolume "39" @default.
- W2084534701 isParatext "false" @default.
- W2084534701 isRetracted "false" @default.
- W2084534701 magId "2084534701" @default.
- W2084534701 workType "letter" @default.