Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084547830> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2084547830 abstract "Abstract A major biologically active Na,K-ATPase inhibitor in the mammalian body may be ouabain-like compound. We investigated the potential roles of circulating ouabain-like compound in the regulation of Na + and K + homeostasis in terms of Na + and K + distribution between the cells and the extracellular fluid (internal balance). First, we developed a population of rats immunized against ouabain to block the action of ouabain-like compound. We measured plasma and intracellular Na + and K + concentrations in skeletal muscle and determined Na + (extracellular-to-intracellular concentration ratio) and K + (intracellular-to-extracellular concentration ratio) gradients in immune rats. We examined also the ability to respond to hypertonic NaCl load in immune rats. Consistent lower plasma K + levels and steeper Na + and K + gradients were observed in immune rats. K + handling in response to hypertonic NaCl load was altered, and lower plasma K + level was maintained in immune rats. Second, we used PST-2238, a newly developed anti-ouabain agent, to block the action of ouabain-like compound and examined its effect on plasma Na + and K + concentrations. Chronic administration of PST-2238 significantly lowered plasma K + levels in rats with subtotal nephrectomy. These findings collectively suggest that ouabain-like compound may determine at least in part the internal Na + and K + distribution and the transmembrane cation gradients in vivo in rats." @default.
- W2084547830 created "2016-06-24" @default.
- W2084547830 creator A5003443371 @default.
- W2084547830 creator A5006782913 @default.
- W2084547830 creator A5034244372 @default.
- W2084547830 creator A5053081928 @default.
- W2084547830 creator A5068584955 @default.
- W2084547830 date "1997-09-01" @default.
- W2084547830 modified "2023-09-30" @default.
- W2084547830 title "Role of Ouabain-like Compound in the Regulation of Transmembrane Sodium and Potassium Gradients in Rats" @default.
- W2084547830 cites W1547942994 @default.
- W2084547830 cites W1640540908 @default.
- W2084547830 cites W1944110753 @default.
- W2084547830 cites W1966809056 @default.
- W2084547830 cites W1982448040 @default.
- W2084547830 cites W1984687894 @default.
- W2084547830 cites W2001243825 @default.
- W2084547830 cites W2017827469 @default.
- W2084547830 cites W2021425630 @default.
- W2084547830 cites W2035186648 @default.
- W2084547830 cites W2050465659 @default.
- W2084547830 cites W2059272518 @default.
- W2084547830 cites W2063060964 @default.
- W2084547830 cites W2069595524 @default.
- W2084547830 cites W2089552799 @default.
- W2084547830 cites W2093166155 @default.
- W2084547830 cites W2126479718 @default.
- W2084547830 cites W2137307314 @default.
- W2084547830 cites W2163165354 @default.
- W2084547830 cites W2346310888 @default.
- W2084547830 cites W2417371868 @default.
- W2084547830 cites W2417675558 @default.
- W2084547830 cites W2435519507 @default.
- W2084547830 cites W2949971533 @default.
- W2084547830 cites W624692098 @default.
- W2084547830 cites W1988877617 @default.
- W2084547830 doi "https://doi.org/10.1161/01.hyp.30.3.753" @default.
- W2084547830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9323018" @default.
- W2084547830 hasPublicationYear "1997" @default.
- W2084547830 type Work @default.
- W2084547830 sameAs 2084547830 @default.
- W2084547830 citedByCount "9" @default.
- W2084547830 countsByYear W20845478302016 @default.
- W2084547830 crossrefType "journal-article" @default.
- W2084547830 hasAuthorship W2084547830A5003443371 @default.
- W2084547830 hasAuthorship W2084547830A5006782913 @default.
- W2084547830 hasAuthorship W2084547830A5034244372 @default.
- W2084547830 hasAuthorship W2084547830A5053081928 @default.
- W2084547830 hasAuthorship W2084547830A5068584955 @default.
- W2084547830 hasConcept C117277713 @default.
- W2084547830 hasConcept C12554922 @default.
- W2084547830 hasConcept C126322002 @default.
- W2084547830 hasConcept C134018914 @default.
- W2084547830 hasConcept C178790620 @default.
- W2084547830 hasConcept C185592680 @default.
- W2084547830 hasConcept C2113261 @default.
- W2084547830 hasConcept C2779133857 @default.
- W2084547830 hasConcept C28406088 @default.
- W2084547830 hasConcept C517785266 @default.
- W2084547830 hasConcept C537181965 @default.
- W2084547830 hasConcept C55493867 @default.
- W2084547830 hasConcept C63645605 @default.
- W2084547830 hasConcept C71924100 @default.
- W2084547830 hasConcept C79879829 @default.
- W2084547830 hasConcept C86803240 @default.
- W2084547830 hasConceptScore W2084547830C117277713 @default.
- W2084547830 hasConceptScore W2084547830C12554922 @default.
- W2084547830 hasConceptScore W2084547830C126322002 @default.
- W2084547830 hasConceptScore W2084547830C134018914 @default.
- W2084547830 hasConceptScore W2084547830C178790620 @default.
- W2084547830 hasConceptScore W2084547830C185592680 @default.
- W2084547830 hasConceptScore W2084547830C2113261 @default.
- W2084547830 hasConceptScore W2084547830C2779133857 @default.
- W2084547830 hasConceptScore W2084547830C28406088 @default.
- W2084547830 hasConceptScore W2084547830C517785266 @default.
- W2084547830 hasConceptScore W2084547830C537181965 @default.
- W2084547830 hasConceptScore W2084547830C55493867 @default.
- W2084547830 hasConceptScore W2084547830C63645605 @default.
- W2084547830 hasConceptScore W2084547830C71924100 @default.
- W2084547830 hasConceptScore W2084547830C79879829 @default.
- W2084547830 hasConceptScore W2084547830C86803240 @default.
- W2084547830 hasLocation W20845478301 @default.
- W2084547830 hasLocation W20845478302 @default.
- W2084547830 hasOpenAccess W2084547830 @default.
- W2084547830 hasPrimaryLocation W20845478301 @default.
- W2084547830 hasRelatedWork W1966041197 @default.
- W2084547830 hasRelatedWork W2012426220 @default.
- W2084547830 hasRelatedWork W2042294732 @default.
- W2084547830 hasRelatedWork W2064228371 @default.
- W2084547830 hasRelatedWork W2076619552 @default.
- W2084547830 hasRelatedWork W216196878 @default.
- W2084547830 hasRelatedWork W2335978439 @default.
- W2084547830 hasRelatedWork W2338294127 @default.
- W2084547830 hasRelatedWork W2400847785 @default.
- W2084547830 hasRelatedWork W2412169769 @default.
- W2084547830 isParatext "false" @default.
- W2084547830 isRetracted "false" @default.
- W2084547830 magId "2084547830" @default.
- W2084547830 workType "article" @default.