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- W2084556666 abstract "Abstract The initial step of pyrimidine biosynthesis in Neurospora crassa , the carbamylation of aspartate to form carbamyl aspartate, is genetically controlled by the pyr-3 locus. Genetic analyses involving recombination, complementation, response to an unlinked suppressor gene, and the ability to suppress other mutant phenotypes divide the locus into at least two functional types of mutant sites. Such a division is supported by biochemical analysis; one functional type characteristically possesses in vitro aspartate transcarbamylase activity, and the second lacks this activity. Kinetic analyses indicate that the enzyme produced by a pyr-3 mutant of N. crassa with an absolute requirement for pyrimidine, yet possessing ATCase activity, is distinguishable from the wild-type enzyme. The results lead to the conclusion that the pyr-3 locus controls two functions: the transcarbamylation of aspartate and a biochemically related function involved in the synthesis of carbamyl phosphate. Mutational alterations of the related function concomitantly alter the kinetics of the transcarbamylase function indicating that both reside on the same protein molecule." @default.
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- W2084556666 date "1968-04-01" @default.
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- W2084556666 title "Genetic control of aspartate transcarbamylase by the pyr-3 locus of Neurospora crassa" @default.
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- W2084556666 doi "https://doi.org/10.1016/0003-9861(68)90631-0" @default.
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