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• W2084582367 startingPage "1381" @default.
• W2084582367 abstract "Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the ligand-activated nuclear receptor superfamily, plays a key role in mediating differentiation of adipocytes and regulating fat metabolism. PPARgamma has been implicated in the pathophysiology of atherosclerosis, inflammation, obesity, diabetes, immune response, and ageing. Recently, it has been shown that activation of PPARgamma by J(2) series cyclopentenone prostaglandins (cyPGs), especially 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) or synthetic agents, such as antidiabetic thiazolidinediones, causes anti-proliferation, apoptosis, differentiation, and anti-inflammation of certain types of cancer cells. The anti-proliferative effects of PPARgamma activators are associated with de novo synthesis of proteins involved in regulating the cell cycle and cell survival/death. Anti-inflammatory effects of 15d-PGJ(2) are associated with interruption of nuclear factor-kappaB and subsequent blockade of inflammatory gene expression. Furthermore, 15d-PGJ(2) at nontoxic doses induce expression of phase II detoxification or stress-responding enzymes, which may confer cellular resistance or adaptation to oxidative stress. The presence of a reactive alpha,beta-unsaturated carbonyl moiety in the cyclopentenone ring of 15d-PGJ(2) is important for part of biological functions this cyPG has. Recently, attention has been focused on the anti-proliferative activity of nonsteroidal anti-inflammatory drugs (NSAIDs) in cancerous or transformed cells, which is mediated through interaction with PPARgamma irrespective of their ability to inhibit COX-2. Despite the fact that abnormally elevated COX-2 is associated with resistance to cell death, induction of apoptosis by certain NSAIDs is accompanied by up-regulation of COX-2 expression. This commentary focuses on dual effects of the typical PPARgamma agonist 15d-PGJ(2) on cell proliferation and growth, and its possible involvement in the NSAID-induced COX-2 expression and apoptosis." @default.
• W2084582367 created "2016-06-24" @default.
• W2084582367 creator A5061532156 @default.
• W2084582367 creator A5072092583 @default.
• W2084582367 date "2003-10-01" @default.
• W2084582367 modified "2023-10-06" @default.
• W2084582367 title "Peroxisome proliferator-activated receptor γ (PPARγ) ligands as bifunctional regulators of cell proliferation" @default.
• W2084582367 cites W1485442945 @default.
• W2084582367 cites W1487129476 @default.
• W2084582367 cites W1487929740 @default.
• W2084582367 cites W1491886022 @default.
• W2084582367 cites W1565693463 @default.
• W2084582367 cites W1587123510 @default.
• W2084582367 cites W1647126819 @default.
• W2084582367 cites W1812573520 @default.
• W2084582367 cites W1964410726 @default.
• W2084582367 cites W1968020616 @default.
• W2084582367 cites W1971090593 @default.
• W2084582367 cites W1971432398 @default.
• W2084582367 cites W1980090453 @default.
• W2084582367 cites W1983855553 @default.
• W2084582367 cites W1989775722 @default.
• W2084582367 cites W1989811320 @default.
• W2084582367 cites W1991631628 @default.
• W2084582367 cites W1993342645 @default.
• W2084582367 cites W1996267589 @default.
• W2084582367 cites W1996508658 @default.
• W2084582367 cites W1997257243 @default.
• W2084582367 cites W2003537519 @default.
• W2084582367 cites W2003699768 @default.
• W2084582367 cites W2013781186 @default.
• W2084582367 cites W2014308014 @default.
• W2084582367 cites W2018726966 @default.
• W2084582367 cites W2022356672 @default.
• W2084582367 cites W2026943045 @default.
• W2084582367 cites W2031694725 @default.
• W2084582367 cites W2033557539 @default.
• W2084582367 cites W2040512344 @default.
• W2084582367 cites W2046892501 @default.
• W2084582367 cites W2050338186 @default.
• W2084582367 cites W2050352100 @default.
• W2084582367 cites W2051057294 @default.
• W2084582367 cites W2058461395 @default.
• W2084582367 cites W2059201682 @default.
• W2084582367 cites W2064618183 @default.
• W2084582367 cites W2071373198 @default.
• W2084582367 cites W2075103181 @default.
• W2084582367 cites W2076935230 @default.
• W2084582367 cites W2077012773 @default.
• W2084582367 cites W2080152431 @default.
• W2084582367 cites W2083290248 @default.
• W2084582367 cites W2084143813 @default.
• W2084582367 cites W2087259247 @default.
• W2084582367 cites W2088404163 @default.
• W2084582367 cites W2090375610 @default.
• W2084582367 cites W2090553336 @default.
• W2084582367 cites W2091124516 @default.
• W2084582367 cites W2091321756 @default.
• W2084582367 cites W2099747965 @default.
• W2084582367 cites W2102998952 @default.
• W2084582367 cites W2107833029 @default.
• W2084582367 cites W2114864434 @default.
• W2084582367 cites W2115338196 @default.
• W2084582367 cites W2117623267 @default.
• W2084582367 cites W2118850680 @default.
• W2084582367 cites W2119863126 @default.
• W2084582367 cites W2120859709 @default.
• W2084582367 cites W2121778299 @default.
• W2084582367 cites W2125497302 @default.
• W2084582367 cites W2136385901 @default.
• W2084582367 cites W2136950996 @default.
• W2084582367 cites W2140014359 @default.
• W2084582367 cites W2145168681 @default.
• W2084582367 cites W2155351530 @default.
• W2084582367 cites W2157008873 @default.
• W2084582367 cites W2157816281 @default.
• W2084582367 cites W2158537424 @default.
• W2084582367 cites W2288906881 @default.
• W2084582367 cites W2318925269 @default.
• W2084582367 cites W4231725887 @default.
• W2084582367 cites W4240789623 @default.
• W2084582367 cites W4296981683 @default.
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• W2084582367 doi "https://doi.org/10.1016/s0006-2952(03)00488-x" @default.
• W2084582367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14555212" @default.
• W2084582367 hasPublicationYear "2003" @default.
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