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- W2084585178 abstract "During kidney development and in response to inductive signals, the metanephric mesenchyme aggregates, becomes polarized, and generates much of the epithelia of the nephron. As such, the metanephric mesenchyme is a renal progenitor cell population that must be replenished as epithelial derivatives are continuously generated. The molecular mechanisms that maintain the undifferentiated state of the metanephric mesenchymal precursor cells have not yet been identified. In this paper, we report that functional inactivation of the homeobox gene Six2 results in premature and ectopic differentiation of mesenchymal cells into epithelia and depletion of the progenitor cell population within the metanephric mesenchyme. Failure to renew the mesenchymal cells results in severe renal hypoplasia. Gain of Six2 function in cortical metanephric mesenchymal cells was sufficient to prevent their epithelial differentiation in an organ culture assay. We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud." @default.
- W2084585178 created "2016-06-24" @default.
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- W2084585178 date "2006-10-12" @default.
- W2084585178 modified "2023-10-02" @default.
- W2084585178 title "Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney" @default.
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- W2084585178 cites W1592260247 @default.
- W2084585178 cites W1765845624 @default.
- W2084585178 cites W1850317612 @default.
- W2084585178 cites W1899130495 @default.
- W2084585178 cites W1922106993 @default.
- W2084585178 cites W1923107379 @default.
- W2084585178 cites W1971238657 @default.
- W2084585178 cites W1971689970 @default.
- W2084585178 cites W1977157996 @default.
- W2084585178 cites W1977466966 @default.
- W2084585178 cites W1982210644 @default.
- W2084585178 cites W1982379359 @default.
- W2084585178 cites W1983228128 @default.
- W2084585178 cites W1993974403 @default.
- W2084585178 cites W1994916683 @default.
- W2084585178 cites W1997631325 @default.
- W2084585178 cites W2002221575 @default.
- W2084585178 cites W2011813261 @default.
- W2084585178 cites W2012494987 @default.
- W2084585178 cites W2013661702 @default.
- W2084585178 cites W2016843954 @default.
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- W2084585178 cites W2053989269 @default.
- W2084585178 cites W2063936800 @default.
- W2084585178 cites W2064537289 @default.
- W2084585178 cites W2065691403 @default.
- W2084585178 cites W2066484100 @default.
- W2084585178 cites W2071263430 @default.
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- W2084585178 cites W2081285491 @default.
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- W2084585178 cites W2142472665 @default.
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- W2084585178 doi "https://doi.org/10.1038/sj.emboj.7601381" @default.
- W2084585178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1630416" @default.
- W2084585178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17036046" @default.
- W2084585178 hasPublicationYear "2006" @default.
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