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• W2084591231 abstract "The pharmacokinetics of moxifloxacin was studied following intravenous (i.v.), intramuscular (i.m.) and oral dose of 5 mg/kg to healthy white New Zealand rabbits ( n = 6). Moxifloxacin concentrations were determined by HPLC assay with fluorescence detection. The moxifloxacin plasma concentration vs. time data after i.v. administration could best be described by a two‐compartment open model. The disposition of i.m. and orally administered moxifloxacin was best described by a one‐compartment model. The plasma moxifloxacin clearance ( Cl ) for the i.v route was (mean ± SD) 0.80 ± 0.02 L/h·kg. The steady‐state volume of distribution ( V ss ) was 1.95 ± 0.18 L/kg. The terminal half‐life ( t 1/2 λ z ) was (mean ± SD) 1.84 ± 0.12, 2.09 ± 0.05 and 2.15 ± 0.07 h after i.v., i.m. and oral, respectively. Minimal inhibitory concentration ( MIC ) assays of moxifloxacin against different strains of S. aureus were performed in order to compute pharmacodynamic surrogate markers. From these data, it is concluded that a 5 mg/kg dose moxifloxacin would be effective by i.m. and oral routes in rabbits against bacterial isolates with MIC ≤ 0.06 μ g/mL and possibly for MIC ≤ 0.12 μ g/mL, but in the latter case a higher dose would be required." @default.
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• W2084591231 date "2005-07-22" @default.
• W2084591231 modified "2023-10-12" @default.
• W2084591231 title "Pharmacokinetic-pharmacodynamic integration of moxifloxacin in rabbits after intravenous, intramuscular and oral administration" @default.
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• W2084591231 doi "https://doi.org/10.1111/j.1365-2885.2005.00665.x" @default.
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