FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084591444> ?p ?o ?g. }

• W2084591444 endingPage "RRN1173" @default.
• W2084591444 startingPage "RRN1173" @default.
• W2084591444 abstract "Increased iron levels have been demonstrated in the basal ganglia of manifest Huntington's disease (HD). An excess in iron accumulation correlates with MRI T2-weighted hypointensity. Determination of the amount of hypointensities in the basal ganglia in the premanifest phase of HD may give more insight in the role of iron in the pathogenesis of HD. Therefore, the present study assessed whether the degree of hypointensities on T2-w MRI in the basal ganglia of premanifest gene carriers differs from non-carriers. Seventeen HD gene carriers without clinical motor signs and 15 non-carriers underwent clinical evaluation and MRI scanning. The amount of T2-w hypointensities was determined using a computer-assisted quantitative method that classified each pixel in the basal ganglia as hypointense or not, resulting in a total of hypointense pixels for each individual. Carriers showed an increased amount of hypointensities in the basal ganglia compared to non-carriers. More hypointensities were furthermore associated with a higher UHDRS total motor score, a longer CAG repeat length and a greater probability of developing symptoms within 5 years. We concluded that the increased amount of hypointensities in the basal ganglia of premanifest carriers of the HD gene may reflect excessive iron deposition and a role for iron in the neuropathology of HD. Furthermore, this phenomenon is associated with clinical and biological disease characteristics. An increased amount of hypointensities on T2-w MRI in the basal ganglia may be considered a biomarker for HD." @default.
• W2084591444 created "2016-06-24" @default.
• W2084591444 creator A5030676110 @default.
• W2084591444 creator A5037097906 @default.
• W2084591444 creator A5044667264 @default.
• W2084591444 creator A5055877229 @default.
• W2084591444 creator A5056596078 @default.
• W2084591444 creator A5061741211 @default.
• W2084591444 creator A5072900370 @default.
• W2084591444 date "2010-09-08" @default.
• W2084591444 modified "2023-09-26" @default.
• W2084591444 title "MRI T2 Hypointensities in basal ganglia of premanifest Huntington's disease" @default.
• W2084591444 cites W160799879 @default.
• W2084591444 cites W1886371827 @default.
• W2084591444 cites W1967922486 @default.
• W2084591444 cites W1969609724 @default.
• W2084591444 cites W1978340256 @default.
• W2084591444 cites W1981835221 @default.
• W2084591444 cites W1986646115 @default.
• W2084591444 cites W1998115145 @default.
• W2084591444 cites W2005953011 @default.
• W2084591444 cites W2008362268 @default.
• W2084591444 cites W2009110155 @default.
• W2084591444 cites W2010754167 @default.
• W2084591444 cites W2022312076 @default.
• W2084591444 cites W2032433220 @default.
• W2084591444 cites W2042631521 @default.
• W2084591444 cites W2047298395 @default.
• W2084591444 cites W2048886113 @default.
• W2084591444 cites W2069832155 @default.
• W2084591444 cites W2076182555 @default.
• W2084591444 cites W2078860848 @default.
• W2084591444 cites W2093131325 @default.
• W2084591444 cites W2095856101 @default.
• W2084591444 cites W2100539976 @default.
• W2084591444 cites W2119039115 @default.
• W2084591444 cites W2123913108 @default.
• W2084591444 cites W2162339143 @default.
• W2084591444 cites W2163671213 @default.
• W2084591444 cites W2606710341 @default.
• W2084591444 cites W2769888961 @default.
• W2084591444 cites W3127623214 @default.
• W2084591444 doi "https://doi.org/10.1371/currents.rrn1173" @default.
• W2084591444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2943244" @default.
• W2084591444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20877453" @default.
• W2084591444 hasPublicationYear "2010" @default.
• W2084591444 type Work @default.
• W2084591444 sameAs 2084591444 @default.
• W2084591444 citedByCount "37" @default.
• W2084591444 countsByYear W20845914442012 @default.
• W2084591444 countsByYear W20845914442013 @default.
• W2084591444 countsByYear W20845914442014 @default.
• W2084591444 countsByYear W20845914442015 @default.
• W2084591444 countsByYear W20845914442016 @default.
• W2084591444 countsByYear W20845914442017 @default.
• W2084591444 countsByYear W20845914442018 @default.
• W2084591444 countsByYear W20845914442019 @default.
• W2084591444 countsByYear W20845914442020 @default.
• W2084591444 countsByYear W20845914442021 @default.
• W2084591444 countsByYear W20845914442022 @default.
• W2084591444 countsByYear W20845914442023 @default.
• W2084591444 crossrefType "journal-article" @default.
• W2084591444 hasAuthorship W2084591444A5030676110 @default.
• W2084591444 hasAuthorship W2084591444A5037097906 @default.
• W2084591444 hasAuthorship W2084591444A5044667264 @default.
• W2084591444 hasAuthorship W2084591444A5055877229 @default.
• W2084591444 hasAuthorship W2084591444A5056596078 @default.
• W2084591444 hasAuthorship W2084591444A5061741211 @default.
• W2084591444 hasAuthorship W2084591444A5072900370 @default.
• W2084591444 hasBestOaLocation W20845914441 @default.
• W2084591444 hasConcept C126322002 @default.
• W2084591444 hasConcept C126838900 @default.
• W2084591444 hasConcept C142724271 @default.
• W2084591444 hasConcept C143409427 @default.
• W2084591444 hasConcept C2778024521 @default.
• W2084591444 hasConcept C2778187257 @default.
• W2084591444 hasConcept C2779134260 @default.
• W2084591444 hasConcept C2779306644 @default.
• W2084591444 hasConcept C2779734285 @default.
• W2084591444 hasConcept C2780130745 @default.
• W2084591444 hasConcept C2780647506 @default.
• W2084591444 hasConcept C2780725373 @default.
• W2084591444 hasConcept C2781197716 @default.
• W2084591444 hasConcept C529278444 @default.
• W2084591444 hasConcept C55493867 @default.
• W2084591444 hasConcept C71924100 @default.
• W2084591444 hasConcept C86803240 @default.
• W2084591444 hasConceptScore W2084591444C126322002 @default.
• W2084591444 hasConceptScore W2084591444C126838900 @default.
• W2084591444 hasConceptScore W2084591444C142724271 @default.
• W2084591444 hasConceptScore W2084591444C143409427 @default.
• W2084591444 hasConceptScore W2084591444C2778024521 @default.
• W2084591444 hasConceptScore W2084591444C2778187257 @default.
• W2084591444 hasConceptScore W2084591444C2779134260 @default.
• W2084591444 hasConceptScore W2084591444C2779306644 @default.
• W2084591444 hasConceptScore W2084591444C2779734285 @default.
• W2084591444 hasConceptScore W2084591444C2780130745 @default.
• W2084591444 hasConceptScore W2084591444C2780647506 @default.

• next