Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084593412> ?p ?o ?g. }
- W2084593412 endingPage "e30140" @default.
- W2084593412 startingPage "e30140" @default.
- W2084593412 abstract "MicroRNAs have gained significant interest due to their widespread occurrence and diverse functions as regulatory molecules, which are essential for cell division, growth, development and apoptosis in eukaryotes. The epidermal growth factor receptor (EGFR) signaling pathway is one of the best investigated cellular signaling pathways regulating important cellular processes and its deregulation is associated with severe diseases, such as cancer. In this study, we introduce a systems biological model of the EGFR signaling pathway integrating validated miRNA-target information according to diverse studies, in order to demonstrate essential roles of miRNA within this pathway. The model consists of 1241 reactions and contains 241 miRNAs. We analyze the impact of 100 specific miRNA inhibitors (anit-miRNAs) on this pathway and propose that the embedded miRNA-network can help to identify new drug targets of the EGFR signaling pathway and thereby support the development of new therapeutic strategies against cancer." @default.
- W2084593412 created "2016-06-24" @default.
- W2084593412 creator A5019720850 @default.
- W2084593412 creator A5028267040 @default.
- W2084593412 creator A5052883326 @default.
- W2084593412 creator A5075632806 @default.
- W2084593412 creator A5091172464 @default.
- W2084593412 date "2012-01-11" @default.
- W2084593412 modified "2023-09-30" @default.
- W2084593412 title "Modeling of miRNA and Drug Action in the EGFR Signaling Pathway" @default.
- W2084593412 cites W144423133 @default.
- W2084593412 cites W1516818607 @default.
- W2084593412 cites W1639582946 @default.
- W2084593412 cites W1648301895 @default.
- W2084593412 cites W1969559178 @default.
- W2084593412 cites W1975304818 @default.
- W2084593412 cites W1976672798 @default.
- W2084593412 cites W1979405589 @default.
- W2084593412 cites W1979413046 @default.
- W2084593412 cites W1985839640 @default.
- W2084593412 cites W1986782449 @default.
- W2084593412 cites W1987851658 @default.
- W2084593412 cites W1988425997 @default.
- W2084593412 cites W1991385244 @default.
- W2084593412 cites W1991674206 @default.
- W2084593412 cites W1992785655 @default.
- W2084593412 cites W1993916353 @default.
- W2084593412 cites W1994979282 @default.
- W2084593412 cites W1996109622 @default.
- W2084593412 cites W2002995168 @default.
- W2084593412 cites W2006888839 @default.
- W2084593412 cites W2019805139 @default.
- W2084593412 cites W2020326055 @default.
- W2084593412 cites W2029375682 @default.
- W2084593412 cites W2030083012 @default.
- W2084593412 cites W2033346155 @default.
- W2084593412 cites W2037180787 @default.
- W2084593412 cites W2038696333 @default.
- W2084593412 cites W2044692345 @default.
- W2084593412 cites W2044962228 @default.
- W2084593412 cites W2052210687 @default.
- W2084593412 cites W2055396579 @default.
- W2084593412 cites W2067647130 @default.
- W2084593412 cites W2074228092 @default.
- W2084593412 cites W2077330022 @default.
- W2084593412 cites W2080084006 @default.
- W2084593412 cites W2083381199 @default.
- W2084593412 cites W2084400739 @default.
- W2084593412 cites W2088953993 @default.
- W2084593412 cites W2091068881 @default.
- W2084593412 cites W2091386059 @default.
- W2084593412 cites W2101410152 @default.
- W2084593412 cites W2102144501 @default.
- W2084593412 cites W2104610341 @default.
- W2084593412 cites W2112880435 @default.
- W2084593412 cites W2113047680 @default.
- W2084593412 cites W2114989000 @default.
- W2084593412 cites W2116799486 @default.
- W2084593412 cites W2117692326 @default.
- W2084593412 cites W2119693744 @default.
- W2084593412 cites W2122205306 @default.
- W2084593412 cites W2125523949 @default.
- W2084593412 cites W2126020004 @default.
- W2084593412 cites W2128286741 @default.
- W2084593412 cites W2129815183 @default.
- W2084593412 cites W2130979840 @default.
- W2084593412 cites W2131636689 @default.
- W2084593412 cites W2138752269 @default.
- W2084593412 cites W2139273728 @default.
- W2084593412 cites W2141547126 @default.
- W2084593412 cites W2144293579 @default.
- W2084593412 cites W2149848115 @default.
- W2084593412 cites W2150705191 @default.
- W2084593412 cites W2150908245 @default.
- W2084593412 cites W2161693225 @default.
- W2084593412 cites W2164194749 @default.
- W2084593412 cites W2165011061 @default.
- W2084593412 cites W2168290712 @default.
- W2084593412 cites W2169354377 @default.
- W2084593412 cites W2329156618 @default.
- W2084593412 cites W4205948329 @default.
- W2084593412 doi "https://doi.org/10.1371/journal.pone.0030140" @default.
- W2084593412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3256223" @default.
- W2084593412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22253908" @default.
- W2084593412 hasPublicationYear "2012" @default.
- W2084593412 type Work @default.
- W2084593412 sameAs 2084593412 @default.
- W2084593412 citedByCount "10" @default.
- W2084593412 countsByYear W20845934122013 @default.
- W2084593412 countsByYear W20845934122014 @default.
- W2084593412 countsByYear W20845934122015 @default.
- W2084593412 countsByYear W20845934122018 @default.
- W2084593412 countsByYear W20845934122019 @default.
- W2084593412 countsByYear W20845934122020 @default.
- W2084593412 countsByYear W20845934122023 @default.
- W2084593412 crossrefType "journal-article" @default.
- W2084593412 hasAuthorship W2084593412A5019720850 @default.
- W2084593412 hasAuthorship W2084593412A5028267040 @default.