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• W2084594954 abstract "We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing four inbred strains (HS4) and a heterogeneous stock (HS-CC) formed from the inbred strain founders of the Collaborative Cross (CC). All three selections were successful, with large differences in haloperidol response emerging within three generations. Using a custom differential network analysis procedure, we found that gene coexpression patterns changed significantly; importantly, a number of these changes were concordant across genetic backgrounds. In contrast, absolute gene-expression changes were modest and not concordant across genetic backgrounds, in spite of the large and similar phenotypic differences. By inferring strain contributions from the parental lines, we are able to identify significant differences in allelic content between the selected lines concurrent with large changes in transcript connectivity. Importantly, this observation implies that genetic polymorphisms can affect transcript and module connectivity without large changes in absolute expression levels. We conclude that, in this case, selective breeding acts at the subnetwork level, with the same modules but not the same transcripts affected across the three selections." @default.
• W2084594954 created "2016-06-24" @default.
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• W2084594954 date "2013-03-21" @default.
• W2084594954 modified "2023-10-07" @default.
• W2084594954 title "Differential Network Analysis Reveals Genetic Effects on Catalepsy Modules" @default.
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• W2084594954 doi "https://doi.org/10.1371/journal.pone.0058951" @default.
• W2084594954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3605410" @default.
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