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- W2084595835 abstract "A highly enantioselective synthesis of (S)-3-aminomethyl-5-methylhexanoic acid 1 (Pregabalin) is reported. The key step of the synthesis is a quinine-mediated ring opening of 3-isobutylglutaric anhydride with cinnamyl alcohol. A Curtius rearrangement and subsequent deprotection provides 1 in high yield and excellent enantiomeric excess." @default.
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- W2084595835 date "2007-07-01" @default.
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- W2084595835 title "An efficient synthesis of (S)-3-aminomethyl-5-methylhexanoic acid (Pregabalin) via quinine-mediated desymmetrization of cyclic anhydride" @default.
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- W2084595835 doi "https://doi.org/10.1016/j.tetasy.2007.06.014" @default.
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