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- W2084601812 abstract "A number of activators are known to increase transcription by RNA polymerase (pol) II through protein acetylation. While the physiological substrates for those acetylases are poorly defined, possible targets include general transcription factors, activator proteins and histones. Using a cell-free system to reconstitute chromatin with increased histone acetylation levels, we directly tested for a causal role of histone acetylation in transcription by RNA pol II. Chromatin, containing either control or acetylated histones, was reconstituted to comparable nucleosome densities and characterized by electron microscopy after psoralen cross-linking as well as by in vitro transcription. While H1-containing control chromatin severely repressed transcription of our model hsp26 gene, highly acetylated chromatin was significantly less repressive. Acetylation of histones, and particularly of histone H4, affected transcription at the level of initiation. Monitoring the ability of the transcription machinery to associate with the promoter in chromatin, we found that heat shock factor, a crucial regulator of heat shock gene transcription, profited most from histone acetylation. These experiments demonstrate that histone acetylation can modulate activator access to their target sites in chromatin, and provide a causal link between histone acetylation and enhanced transcription initiation of RNA pol II in chromatin." @default.
- W2084601812 created "2016-06-24" @default.
- W2084601812 creator A5023162557 @default.
- W2084601812 date "1998-05-15" @default.
- W2084601812 modified "2023-10-01" @default.
- W2084601812 title "Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin" @default.
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- W2084601812 cites W1540264737 @default.
- W2084601812 cites W1548972556 @default.
- W2084601812 cites W1587031596 @default.
- W2084601812 cites W1590436404 @default.
- W2084601812 cites W1620884108 @default.
- W2084601812 cites W1633318893 @default.
- W2084601812 cites W1737975759 @default.
- W2084601812 cites W1756254534 @default.
- W2084601812 cites W1857899292 @default.
- W2084601812 cites W1867803130 @default.
- W2084601812 cites W1921479150 @default.
- W2084601812 cites W1964056324 @default.
- W2084601812 cites W1966499692 @default.
- W2084601812 cites W1967769642 @default.
- W2084601812 cites W1974903866 @default.
- W2084601812 cites W1978373330 @default.
- W2084601812 cites W1985063313 @default.
- W2084601812 cites W1987271093 @default.
- W2084601812 cites W1989968124 @default.
- W2084601812 cites W1990958396 @default.
- W2084601812 cites W1993550737 @default.
- W2084601812 cites W1997478944 @default.
- W2084601812 cites W1998220537 @default.
- W2084601812 cites W1998904806 @default.
- W2084601812 cites W2000160072 @default.
- W2084601812 cites W2000939708 @default.
- W2084601812 cites W2006922495 @default.
- W2084601812 cites W2007227478 @default.
- W2084601812 cites W2008409661 @default.
- W2084601812 cites W2012016447 @default.
- W2084601812 cites W2013050831 @default.
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- W2084601812 cites W2030571655 @default.
- W2084601812 cites W2030645111 @default.
- W2084601812 cites W2034678820 @default.
- W2084601812 cites W2037432162 @default.
- W2084601812 cites W2038610446 @default.
- W2084601812 cites W2038661934 @default.
- W2084601812 cites W2038936819 @default.
- W2084601812 cites W2040138954 @default.
- W2084601812 cites W2041309113 @default.
- W2084601812 cites W2045777848 @default.
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- W2084601812 cites W2055593542 @default.
- W2084601812 cites W2057782567 @default.
- W2084601812 cites W2058817177 @default.
- W2084601812 cites W2062514148 @default.
- W2084601812 cites W2065721092 @default.
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- W2084601812 cites W2070159701 @default.
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- W2084601812 cites W2135522516 @default.
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- W2084601812 cites W2157180918 @default.
- W2084601812 cites W2159348779 @default.
- W2084601812 cites W2163964409 @default.
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- W2084601812 doi "https://doi.org/10.1093/emboj/17.10.2865" @default.
- W2084601812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1170627" @default.
- W2084601812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9582280" @default.
- W2084601812 hasPublicationYear "1998" @default.
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