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• W2084602178 abstract "Although a role for monocytes and monocyte-derived dendritic cells (DC) in the activation of T cells is well established, it is less clear to what extent DC and their precursors, monocytes, regulate B cell immune responses. Here we show that regulatory mechanisms similar to those in humans are in place in the bovine immune system. In vitro culture of bovine monocytes with bovine B cells activated by the anti-CD3 triggered CD4+ T cells or through immunoglobulin (Ig) receptor crosslinking induces B cell Ig secretion. Unlike bovine monocyte-derived DC, monocytes do not promote Ig class switching to IgG and IgA in activated peripheral blood B cells. These results suggest that bovine monocytes are capable of directly inducing Ig secretion in activated bovine peripheral blood B cells, but do not provide the signals for B cell Ig class switching." @default.
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• W2084602178 date "2003-12-01" @default.
• W2084602178 modified "2023-09-26" @default.
• W2084602178 title "Bovine monocytes induce immunoglobulin production in peripheral blood B lymphocytes" @default.
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• W2084602178 doi "https://doi.org/10.1016/s0145-305x(03)00080-6" @default.
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