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• W2084650972 abstract "In the two-stage rat bladder carcinogenesis model using N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) as an initiator and sodium l-ascorbate (SA) as a promoter, we found a notable strain difference between F344/DuCrj (F344) and WS/Shi (WS) rats in susceptibility to the promoting effect of SA. Twenty each of F344, WS and reciprocal F1 hybrid rats were given 0.05% BBN in their drinking water for 4 weeks and then a basal diet with (BBN-SA group) or without (BBN group) a 5% SA supplement for 32 weeks. In F344 and also in reciprocal F1 hybrids, the number of tumors per rat was significantly higher in the BBN-SA group than in the BBN group (P<0.0001). In contrast, WS rats were not significantly affected by either treatment (P=0.8). These findings indicate that F344 rats are highly susceptible to the promoter effect of SA, but WS rats are not. Linkage analysis of 108 WS X (WSXF344) F1 backcrosses revealed that this difference was related to a quantitative trait locus mapped on rat Chr. 17 (maximum LOD score, 3.86) named Bladder Tumor Susceptible-I and possibly another locus on Chr. 5 (maximum LOD score, 2.39). This study has provided the first evidence that host genes influence the risk of bladder cancer development." @default.
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• W2084650972 date "1997-07-01" @default.
• W2084650972 modified "2023-10-16" @default.
• W2084650972 title "Quantitative Trait Loci Associated with Promoting Effects of Sodiuml-Ascorbate on Two-stage Bladder Carcinogenesis in Rats" @default.
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• W2084650972 doi "https://doi.org/10.1111/j.1349-7006.1997.tb00430.x" @default.
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