FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084654316> ?p ?o ?g. }

• W2084654316 endingPage "1419" @default.
• W2084654316 startingPage "1412" @default.
• W2084654316 abstract "Hyperuricemia is a common feature of patients with non-alcoholic fatty liver disease (NAFLD). This study aimed to explore the causal relationship and underlying mechanisms between NAFLD and hyperuricemia.We evaluated the impact of NAFLD on the development of hyperuricemia in a cohort of 5541 baseline hyperuricemia-free individuals. We further analyzed xanthine oxidase (XO), a rate-limiting enzyme that catalyzes uric acid production, as a candidate to link NAFLD and hyperuricemia.In the first study, a 7-year prospective analysis found that NAFLD was strongly associated with subsequent development of hyperuricemia. Cox proportional hazards regression analyses showed that age, gender, and body mass index adjusted hazard ratio (95% confidence interval) for incident hyperuricemia was 1.609 (1.129-2.294) in individuals with NAFLD, as compared with those without NAFLD at baseline. In the second study, we observed that expression and activity of XO were significantly increased in cellular and mouse models of NAFLD. Knocking down XO expression or inhibiting XO activity significantly decreases uric acid production and attenuates free fatty acids-induced fat accumulation in HepG2 cells. Inhibiting XO activity also significantly prevents the development of and ameliorates established hepatic steatosis induced by a high-fat diet in mice. Further experiments indicated that XO regulates activation of the NLRP3 inflammasome, which may be essential for the regulatory effect of XO on NAFLD.NAFLD significantly increases the risk of incident hyperuricemia. XO is a mediator of the relationship between NAFLD and hyperuricemia, and may serve as a novel therapeutic target for the two linked diseases." @default.
• W2084654316 created "2016-06-24" @default.
• W2084654316 creator A5007334067 @default.
• W2084654316 creator A5034033533 @default.
• W2084654316 creator A5034774874 @default.
• W2084654316 creator A5054147665 @default.
• W2084654316 creator A5058204085 @default.
• W2084654316 creator A5074699954 @default.
• W2084654316 creator A5080796027 @default.
• W2084654316 creator A5080885482 @default.
• W2084654316 creator A5081027138 @default.
• W2084654316 creator A5082474292 @default.
• W2084654316 creator A5086839633 @default.
• W2084654316 date "2015-06-01" @default.
• W2084654316 modified "2023-10-01" @default.
• W2084654316 title "Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds" @default.
• W2084654316 cites W1963683487 @default.
• W2084654316 cites W1965423912 @default.
• W2084654316 cites W1971851436 @default.
• W2084654316 cites W1973450715 @default.
• W2084654316 cites W1985538633 @default.
• W2084654316 cites W1986731647 @default.
• W2084654316 cites W1988826453 @default.
• W2084654316 cites W2000286133 @default.
• W2084654316 cites W2006292992 @default.
• W2084654316 cites W2009435405 @default.
• W2084654316 cites W2009800174 @default.
• W2084654316 cites W2020193393 @default.
• W2084654316 cites W2021240626 @default.
• W2084654316 cites W2022621797 @default.
• W2084654316 cites W2024984581 @default.
• W2084654316 cites W2030666214 @default.
• W2084654316 cites W2034527070 @default.
• W2084654316 cites W2034946303 @default.
• W2084654316 cites W2035657846 @default.
• W2084654316 cites W2040109162 @default.
• W2084654316 cites W2047257800 @default.
• W2084654316 cites W2048032544 @default.
• W2084654316 cites W2063514709 @default.
• W2084654316 cites W2070176615 @default.
• W2084654316 cites W2076244923 @default.
• W2084654316 cites W2078060476 @default.
• W2084654316 cites W2090548255 @default.
• W2084654316 cites W2101208273 @default.
• W2084654316 cites W2106272645 @default.
• W2084654316 cites W2112291880 @default.
• W2084654316 cites W2113511371 @default.
• W2084654316 cites W2113546508 @default.
• W2084654316 cites W2128190429 @default.
• W2084654316 cites W2136795008 @default.
• W2084654316 cites W2137630620 @default.
• W2084654316 cites W2144275312 @default.
• W2084654316 cites W2148113831 @default.
• W2084654316 cites W2149863634 @default.
• W2084654316 cites W2150702412 @default.
• W2084654316 cites W2171212614 @default.
• W2084654316 cites W2171576765 @default.
• W2084654316 cites W2269946328 @default.
• W2084654316 cites W2885323148 @default.
• W2084654316 cites W4376849355 @default.
• W2084654316 doi "https://doi.org/10.1016/j.jhep.2015.01.019" @default.
• W2084654316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25623823" @default.
• W2084654316 hasPublicationYear "2015" @default.
• W2084654316 type Work @default.
• W2084654316 sameAs 2084654316 @default.
• W2084654316 citedByCount "114" @default.
• W2084654316 countsByYear W20846543162015 @default.
• W2084654316 countsByYear W20846543162016 @default.
• W2084654316 countsByYear W20846543162017 @default.
• W2084654316 countsByYear W20846543162018 @default.
• W2084654316 countsByYear W20846543162019 @default.
• W2084654316 countsByYear W20846543162020 @default.
• W2084654316 countsByYear W20846543162021 @default.
• W2084654316 countsByYear W20846543162022 @default.
• W2084654316 countsByYear W20846543162023 @default.
• W2084654316 crossrefType "journal-article" @default.
• W2084654316 hasAuthorship W2084654316A5007334067 @default.
• W2084654316 hasAuthorship W2084654316A5034033533 @default.
• W2084654316 hasAuthorship W2084654316A5034774874 @default.
• W2084654316 hasAuthorship W2084654316A5054147665 @default.
• W2084654316 hasAuthorship W2084654316A5058204085 @default.
• W2084654316 hasAuthorship W2084654316A5074699954 @default.
• W2084654316 hasAuthorship W2084654316A5080796027 @default.
• W2084654316 hasAuthorship W2084654316A5080885482 @default.
• W2084654316 hasAuthorship W2084654316A5081027138 @default.
• W2084654316 hasAuthorship W2084654316A5082474292 @default.
• W2084654316 hasAuthorship W2084654316A5086839633 @default.
• W2084654316 hasConcept C126322002 @default.
• W2084654316 hasConcept C134018914 @default.
• W2084654316 hasConcept C181199279 @default.
• W2084654316 hasConcept C185592680 @default.
• W2084654316 hasConcept C207103383 @default.
• W2084654316 hasConcept C2776175330 @default.
• W2084654316 hasConcept C2778102346 @default.
• W2084654316 hasConcept C2778772119 @default.
• W2084654316 hasConcept C2779134260 @default.
• W2084654316 hasConcept C2779721657 @default.
• W2084654316 hasConcept C2779881121 @default.

• next