FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084679368> ?p ?o ?g. }

• W2084679368 endingPage "1857" @default.
• W2084679368 startingPage "1846" @default.
• W2084679368 abstract "Steroid hormones can influence neuronal excitability and subsequent seizure susceptibility through genomic and nongenomic mechanisms. For example, there are proconvulsant steroids such as estradiol and corticosterone and anticonvulsant steroids such as testosterone, progesterone, and their GABAergic metabolites. Recent findings indicated that a single, acute administration of ethanol increased levels of GABAergic steroids and that the source of this increase was peripheral organs such as the adrenals and gonads. Thus, the purpose of the present study was to determine the impact of removal of the adrenals and/or gonads on withdrawal severity following a single high dose of ethanol in 2 genotypes that differ in ethanol withdrawal severity.Male and female C57BL/6J (B6) and DBA/2J (D2) mice were either left intact (SHAM), adrenalectomized (ADX), gonadectomized (GDX), or underwent ADX/GDX surgery. Seven days following surgery, baseline handling-induced convulsions (HICs) were measured prior to administration of a 4 g/kg dose of ethanol. HICs were assessed following the ethanol injection, then hourly for 12 hours and at 24 hours. A separate group of mice were used to measure the impact of surgical status on ethanol metabolism at 30, 60, 120, and 240 minutes after a single 4 g/kg dose of ethanol.ADX and ADX/GDX treatments in male B6 and D2 mice increased ethanol withdrawal severity following a single dose of ethanol, measured by area under the withdrawal curve and peak HIC scores. Acute ethanol withdrawal also was increased in female D2 mice that had undergone ADX/GDX. In contrast, surgical status did not alter ethanol withdrawal severity in female B6 mice. Surgical status had only minor effects on ethanol metabolism.Removal of peripherally derived steroids with anticonvulsant properties significantly increased HIC scores during acute ethanol withdrawal following a single dose of ethanol in male and female D2 mice and in male B6 mice. These increases were not due to changes in ethanol metabolism." @default.
• W2084679368 created "2016-06-24" @default.
• W2084679368 creator A5029760103 @default.
• W2084679368 creator A5041043150 @default.
• W2084679368 date "2007-11-01" @default.
• W2084679368 modified "2023-09-24" @default.
• W2084679368 title "The Impact of Gonadectomy and Adrenalectomy on Acute Withdrawal Severity in Male and Female C57BL/6J and DBA/2J Mice Following a Single High Dose of Ethanol" @default.
• W2084679368 cites W1618814156 @default.
• W2084679368 cites W1922154348 @default.
• W2084679368 cites W1945375049 @default.
• W2084679368 cites W1966397423 @default.
• W2084679368 cites W1967605643 @default.
• W2084679368 cites W1971108844 @default.
• W2084679368 cites W1971831953 @default.
• W2084679368 cites W1974150203 @default.
• W2084679368 cites W1980844720 @default.
• W2084679368 cites W1980893233 @default.
• W2084679368 cites W1983229473 @default.
• W2084679368 cites W1985013425 @default.
• W2084679368 cites W1986775988 @default.
• W2084679368 cites W1991641846 @default.
• W2084679368 cites W1993427526 @default.
• W2084679368 cites W1994534741 @default.
• W2084679368 cites W2000711631 @default.
• W2084679368 cites W2002126014 @default.
• W2084679368 cites W2009374253 @default.
• W2084679368 cites W2013777991 @default.
• W2084679368 cites W2019183259 @default.
• W2084679368 cites W2019452769 @default.
• W2084679368 cites W2023261925 @default.
• W2084679368 cites W2024350454 @default.
• W2084679368 cites W2027024772 @default.
• W2084679368 cites W2030295462 @default.
• W2084679368 cites W2031079587 @default.
• W2084679368 cites W2031193882 @default.
• W2084679368 cites W2031458111 @default.
• W2084679368 cites W2034245208 @default.
• W2084679368 cites W2036348103 @default.
• W2084679368 cites W2037919944 @default.
• W2084679368 cites W2039299884 @default.
• W2084679368 cites W2044005169 @default.
• W2084679368 cites W2048623190 @default.
• W2084679368 cites W2048706813 @default.
• W2084679368 cites W2050844190 @default.
• W2084679368 cites W2052005906 @default.
• W2084679368 cites W2058404259 @default.
• W2084679368 cites W2065760031 @default.
• W2084679368 cites W2067260885 @default.
• W2084679368 cites W2077468380 @default.
• W2084679368 cites W2082193361 @default.
• W2084679368 cites W2082269355 @default.
• W2084679368 cites W2090339546 @default.
• W2084679368 cites W2093826327 @default.
• W2084679368 cites W2094317640 @default.
• W2084679368 cites W2095016919 @default.
• W2084679368 cites W2115707323 @default.
• W2084679368 cites W2118773914 @default.
• W2084679368 cites W2118790060 @default.
• W2084679368 cites W2130287184 @default.
• W2084679368 cites W2143436974 @default.
• W2084679368 cites W2148377354 @default.
• W2084679368 cites W2160829410 @default.
• W2084679368 cites W2169142987 @default.
• W2084679368 cites W2269710144 @default.
• W2084679368 cites W2271577444 @default.
• W2084679368 cites W2280509672 @default.
• W2084679368 cites W2471769085 @default.
• W2084679368 cites W4242836676 @default.
• W2084679368 cites W4245117662 @default.
• W2084679368 cites W4301495396 @default.
• W2084679368 doi "https://doi.org/10.1111/j.1530-0277.2007.00509.x" @default.
• W2084679368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2807885" @default.
• W2084679368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17850218" @default.
• W2084679368 hasPublicationYear "2007" @default.
• W2084679368 type Work @default.
• W2084679368 sameAs 2084679368 @default.
• W2084679368 citedByCount "22" @default.
• W2084679368 countsByYear W20846793682012 @default.
• W2084679368 countsByYear W20846793682013 @default.
• W2084679368 countsByYear W20846793682014 @default.
• W2084679368 countsByYear W20846793682016 @default.
• W2084679368 countsByYear W20846793682017 @default.
• W2084679368 countsByYear W20846793682020 @default.
• W2084679368 countsByYear W20846793682021 @default.
• W2084679368 countsByYear W20846793682023 @default.
• W2084679368 crossrefType "journal-article" @default.
• W2084679368 hasAuthorship W2084679368A5029760103 @default.
• W2084679368 hasAuthorship W2084679368A5041043150 @default.
• W2084679368 hasBestOaLocation W20846793682 @default.
• W2084679368 hasConcept C126322002 @default.
• W2084679368 hasConcept C134018914 @default.
• W2084679368 hasConcept C142724271 @default.
• W2084679368 hasConcept C178790620 @default.
• W2084679368 hasConcept C185592680 @default.
• W2084679368 hasConcept C204787440 @default.
• W2084679368 hasConcept C2775961468 @default.
• W2084679368 hasConcept C2779279991 @default.
• W2084679368 hasConcept C2780087391 @default.

• next