Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084710095> ?p ?o ?g. }
- W2084710095 endingPage "1338" @default.
- W2084710095 startingPage "1315" @default.
- W2084710095 abstract "Helicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. Some inhibitors have also been shown to decrease viral replication in cell culture and animal models. This review discusses recent progress in understanding the structure and function of viral helicases to help clarify how these potential antiviral compounds function and to facilitate the design of better inhibitors. The above helicases and all related viral proteins are classified here based on their evolutionary and functional similarities, and the key mechanistic features of each group are noted. All helicases share a common motor function fueled by ATP hydrolysis, but differ in exactly how the motor moves the protein and its cargo on a nucleic acid chain. The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor. Keywords: enzyme mechanism, motor proteins, DExD/H-box proteins, ATPase" @default.
- W2084710095 created "2016-06-24" @default.
- W2084710095 creator A5033704361 @default.
- W2084710095 creator A5060924856 @default.
- W2084710095 date "2006-04-01" @default.
- W2084710095 modified "2023-09-27" @default.
- W2084710095 title "Understanding Helicases as a Means of Virus Control" @default.
- W2084710095 cites W124504601 @default.
- W2084710095 cites W1481507615 @default.
- W2084710095 cites W1484205352 @default.
- W2084710095 cites W1497983649 @default.
- W2084710095 cites W1509876975 @default.
- W2084710095 cites W1513995144 @default.
- W2084710095 cites W1514376968 @default.
- W2084710095 cites W1521918462 @default.
- W2084710095 cites W1523207280 @default.
- W2084710095 cites W1533124451 @default.
- W2084710095 cites W1534872681 @default.
- W2084710095 cites W1535629580 @default.
- W2084710095 cites W1538074723 @default.
- W2084710095 cites W1539862442 @default.
- W2084710095 cites W1546095443 @default.
- W2084710095 cites W1556270435 @default.
- W2084710095 cites W1560819028 @default.
- W2084710095 cites W1582754056 @default.
- W2084710095 cites W1595354886 @default.
- W2084710095 cites W1607071909 @default.
- W2084710095 cites W1657824585 @default.
- W2084710095 cites W1759069886 @default.
- W2084710095 cites W1824711428 @default.
- W2084710095 cites W1897467108 @default.
- W2084710095 cites W1901126754 @default.
- W2084710095 cites W1902535716 @default.
- W2084710095 cites W1908985082 @default.
- W2084710095 cites W1950162085 @default.
- W2084710095 cites W1963485674 @default.
- W2084710095 cites W1963739817 @default.
- W2084710095 cites W1964317548 @default.
- W2084710095 cites W1965280032 @default.
- W2084710095 cites W1966027421 @default.
- W2084710095 cites W1968747413 @default.
- W2084710095 cites W1969862311 @default.
- W2084710095 cites W1969965681 @default.
- W2084710095 cites W1970118751 @default.
- W2084710095 cites W1970864226 @default.
- W2084710095 cites W1971038208 @default.
- W2084710095 cites W1972609517 @default.
- W2084710095 cites W1972895358 @default.
- W2084710095 cites W1972973591 @default.
- W2084710095 cites W1973357632 @default.
- W2084710095 cites W1973707734 @default.
- W2084710095 cites W1975366693 @default.
- W2084710095 cites W1975520452 @default.
- W2084710095 cites W1975678284 @default.
- W2084710095 cites W1976491544 @default.
- W2084710095 cites W1976933659 @default.
- W2084710095 cites W1977494316 @default.
- W2084710095 cites W1979951684 @default.
- W2084710095 cites W1980145808 @default.
- W2084710095 cites W1982003972 @default.
- W2084710095 cites W1982895273 @default.
- W2084710095 cites W1983575279 @default.
- W2084710095 cites W1984067942 @default.
- W2084710095 cites W1985008932 @default.
- W2084710095 cites W1985198279 @default.
- W2084710095 cites W1985907558 @default.
- W2084710095 cites W1986079776 @default.
- W2084710095 cites W1987350137 @default.
- W2084710095 cites W1988237823 @default.
- W2084710095 cites W1989340932 @default.
- W2084710095 cites W1989396934 @default.
- W2084710095 cites W1992180542 @default.
- W2084710095 cites W1992555511 @default.
- W2084710095 cites W1994253720 @default.
- W2084710095 cites W1996320201 @default.
- W2084710095 cites W1997714902 @default.
- W2084710095 cites W1997843363 @default.
- W2084710095 cites W1998093640 @default.
- W2084710095 cites W2001087850 @default.
- W2084710095 cites W2001458172 @default.
- W2084710095 cites W2002669881 @default.
- W2084710095 cites W2004236691 @default.
- W2084710095 cites W2004584518 @default.
- W2084710095 cites W2005916059 @default.
- W2084710095 cites W2006041259 @default.
- W2084710095 cites W2006193339 @default.
- W2084710095 cites W2008018538 @default.
- W2084710095 cites W2008052842 @default.
- W2084710095 cites W2008653125 @default.
- W2084710095 cites W2010646955 @default.
- W2084710095 cites W2013010199 @default.
- W2084710095 cites W2013379888 @default.
- W2084710095 cites W2013532544 @default.
- W2084710095 cites W2013905198 @default.
- W2084710095 cites W2013982103 @default.
- W2084710095 cites W2015195844 @default.
- W2084710095 cites W2015316756 @default.
- W2084710095 cites W2015422697 @default.