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- W2084724451 abstract "Aim To study the antimicrobial effect in vitro of hexylene glycol and mometasone furoate fatty cream (contains 12% hexylene glycol) and to study the effect of mometasone furoate fatty cream on clinical parameters and microbial flora in patients with atopic dermatitis.Methods The effect of hexylene glycol and mometasone furoate fatty cream against Staphylococcus aureus, S. epidermidis, Pityrosporum ovale and Candida albicans was studied in vitro. Twenty patients with moderate to severe atopic dermatitis were treated with mometasone furoate 0.1% fatty cream once daily for 3 weeks and then intermittently for 3 weeks. Quantitative cultures for bacteria and fungi were taken at baseline, during treatment and 4 weeks after end of treatment.Results Both hexylene glycol and mometasone furoate fatty cream were effective in vitro against the studied microorganisms. Thirteen of 18 patients who returned for control were cleared after 3 weeks of treatment and 1518 patients or 83% were cleared after 6 weeks. Four weeks after end of treatment only one patient remained cleared. However, 1114 patients who returned for this control were still improved compared to baseline. S. aureus was cultured in 1620 patients at baseline but in only 7/18 patients after 6 weeks of treatment. The number of S. aureus dropped significantly but increased two-fold 4 weeks after end of treatment. The number of cultured P. ovale was also significantly reduced after 6 weeks.Conclusion This study clearly demonstrate the good effect of mometasone furoate fatty cream, which contains 12% hexylene glycol, in the treatment of atopic dermatitis paralleled by a significant reduction in the number of S. aureus and P. ovale." @default.
- W2084724451 created "2016-06-24" @default.
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- W2084724451 date "1997-05-01" @default.
- W2084724451 modified "2023-09-27" @default.
- W2084724451 title "A pilot study on the efficacy of mometasone furoate fatty cream on clinical parameters, time to relapse and microbial flora in atopic dermatitis" @default.
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- W2084724451 doi "https://doi.org/10.1111/j.1468-3083.1997.tb00482.x" @default.
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