Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084735541> ?p ?o ?g. }
- W2084735541 endingPage "168" @default.
- W2084735541 startingPage "150" @default.
- W2084735541 abstract "Formaldehyde is an economically important chemical, to which more than 2 million U.S. workers are occupationally exposed. Substantially more people are exposed to formaldehyde environmentally, as it is generated by automobile engines, is a component of tobacco smoke and is released from household products, including furniture, particleboard, plywood, and carpeting. The International Agency for Research on Cancer (IARC) recently classified formaldehyde as a human carcinogen that causes nasopharyngeal cancer and also concluded that there is strong but not sufficient evidence for a causal association between leukemia and occupational exposure to Here, we review the epidemiological studies published to date on formaldehyde-exposed workers and professionals in relation to lymphohematopoietic malignances. In a new meta-analysis of these studies, focusing on occupations known to have high formaldehyde exposure, we show that summary relative risks (RRs) were elevated in 15 studies of leukemia (RR=1.54; confidence interval (CI), 1.18-2.00) with the highest relative risks seen in the six studies of myeloid leukemia (RR=1.90; 95% CI, 1.31-2.76). The biological plausibility of this observed association is discussed and potential mechanisms proposed. We hypothesize that formaldehyde may act on bone marrow directly or, alternatively, may cause leukemia by damaging the hematopoietic stem or early progenitor cells that are located in the circulating blood or nasal passages, which then travel to the bone marrow and become leukemic stem cells. To test these hypotheses, we recommend that future studies apply biomarkers validated for other chemical leukemogens to the study of formaldehyde." @default.
- W2084735541 created "2016-06-24" @default.
- W2084735541 creator A5010924875 @default.
- W2084735541 creator A5068037678 @default.
- W2084735541 creator A5076596700 @default.
- W2084735541 creator A5077764537 @default.
- W2084735541 creator A5081201696 @default.
- W2084735541 date "2009-03-01" @default.
- W2084735541 modified "2023-10-06" @default.
- W2084735541 title "Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms" @default.
- W2084735541 cites W1558352148 @default.
- W2084735541 cites W1719320996 @default.
- W2084735541 cites W1749666505 @default.
- W2084735541 cites W1848098399 @default.
- W2084735541 cites W1964435302 @default.
- W2084735541 cites W1965604268 @default.
- W2084735541 cites W1965821049 @default.
- W2084735541 cites W1966026905 @default.
- W2084735541 cites W1966129972 @default.
- W2084735541 cites W1966577477 @default.
- W2084735541 cites W1967762868 @default.
- W2084735541 cites W1973661030 @default.
- W2084735541 cites W1977380541 @default.
- W2084735541 cites W1978473096 @default.
- W2084735541 cites W1979006814 @default.
- W2084735541 cites W1979047189 @default.
- W2084735541 cites W1980061128 @default.
- W2084735541 cites W1980624173 @default.
- W2084735541 cites W1980787460 @default.
- W2084735541 cites W1981100578 @default.
- W2084735541 cites W1984646350 @default.
- W2084735541 cites W1985178977 @default.
- W2084735541 cites W1986375828 @default.
- W2084735541 cites W1987247874 @default.
- W2084735541 cites W1987863060 @default.
- W2084735541 cites W1989031041 @default.
- W2084735541 cites W1991033174 @default.
- W2084735541 cites W1992051582 @default.
- W2084735541 cites W1993734741 @default.
- W2084735541 cites W1995131927 @default.
- W2084735541 cites W1995582229 @default.
- W2084735541 cites W1996253124 @default.
- W2084735541 cites W1997688465 @default.
- W2084735541 cites W1998977935 @default.
- W2084735541 cites W2004096727 @default.
- W2084735541 cites W2010071686 @default.
- W2084735541 cites W2010957401 @default.
- W2084735541 cites W2011334470 @default.
- W2084735541 cites W2011346684 @default.
- W2084735541 cites W2013554057 @default.
- W2084735541 cites W2015686499 @default.
- W2084735541 cites W2016739029 @default.
- W2084735541 cites W2016763486 @default.
- W2084735541 cites W2016907191 @default.
- W2084735541 cites W2018256515 @default.
- W2084735541 cites W2019221183 @default.
- W2084735541 cites W2019633560 @default.
- W2084735541 cites W2019960419 @default.
- W2084735541 cites W2021273569 @default.
- W2084735541 cites W2021518672 @default.
- W2084735541 cites W2021887265 @default.
- W2084735541 cites W2021937412 @default.
- W2084735541 cites W2022520864 @default.
- W2084735541 cites W2025553091 @default.
- W2084735541 cites W2028819855 @default.
- W2084735541 cites W2031349740 @default.
- W2084735541 cites W2031357438 @default.
- W2084735541 cites W2034466450 @default.
- W2084735541 cites W2036407540 @default.
- W2084735541 cites W2038373046 @default.
- W2084735541 cites W2040773878 @default.
- W2084735541 cites W2040817861 @default.
- W2084735541 cites W2042465365 @default.
- W2084735541 cites W2043634235 @default.
- W2084735541 cites W2044115264 @default.
- W2084735541 cites W2046060788 @default.
- W2084735541 cites W2048724186 @default.
- W2084735541 cites W2049798100 @default.
- W2084735541 cites W2051210875 @default.
- W2084735541 cites W2052588544 @default.
- W2084735541 cites W2053281770 @default.
- W2084735541 cites W2054534251 @default.
- W2084735541 cites W2055085312 @default.
- W2084735541 cites W2056905244 @default.
- W2084735541 cites W2057337864 @default.
- W2084735541 cites W2064452607 @default.
- W2084735541 cites W2066194016 @default.
- W2084735541 cites W2066525085 @default.
- W2084735541 cites W2067427721 @default.
- W2084735541 cites W2071867046 @default.
- W2084735541 cites W2073111451 @default.
- W2084735541 cites W2073587565 @default.
- W2084735541 cites W2078813638 @default.
- W2084735541 cites W2079895003 @default.
- W2084735541 cites W2083350807 @default.
- W2084735541 cites W2084630860 @default.
- W2084735541 cites W2086149372 @default.
- W2084735541 cites W2088810136 @default.