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- W2084736142 abstract "Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers; after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen." @default.
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- W2084736142 date "1979-08-01" @default.
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- W2084736142 title "Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats" @default.
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- W2084736142 doi "https://doi.org/10.1038/bjc.1979.174" @default.
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