Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084741276> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2084741276 endingPage "221" @default.
- W2084741276 startingPage "211" @default.
- W2084741276 abstract "We have developed a general method for the detection of beta-blockers and/or of their metabolites in human urine. The method comprises a pretreatment procedure (enzymatic hydrolysis, liquid/liquid extraction and derivatization by pentafluoropropionic anhydride, PFPA), carried out on an initial aliquot of 2.5-5.0 ml of urine, and the instrumental analysis of the derivatives, performed by GC-MS-MS (ion trap) with electronic impact ionization (EI). The GC-MS-MS analysis allows to isolate and to characterize specific fragments of the original molecular structure, and particularly the fragments originating from parent ion clusters specific for all beta blocking drugs, giving rise to m/z = 366 and 202 ions respectively. MS-MS analysis of the parent ion allows checking for the presence of the above-mentioned peaks in the GC-MS chromatogram. The proposed method is capable of detecting a great variety of known (and possibly also of newly synthesized) beta-blockers, with an average sensitivity limit of 20 ng/ml of drug/metabolite in urine. The method is presently being evaluated as a general screening protocol to be followed by an antidoping laboratory to detect illicit beta-blockers administration to the athletes." @default.
- W2084741276 created "2016-06-24" @default.
- W2084741276 creator A5015298982 @default.
- W2084741276 creator A5031921158 @default.
- W2084741276 creator A5081994437 @default.
- W2084741276 date "2000-08-01" @default.
- W2084741276 modified "2023-10-13" @default.
- W2084741276 title "Detection of beta-blockers in human urine by GC-MS-MS-EI: perspectives for the antidoping control" @default.
- W2084741276 cites W185891161 @default.
- W2084741276 cites W2013840671 @default.
- W2084741276 cites W2025903445 @default.
- W2084741276 cites W2040006738 @default.
- W2084741276 cites W2041534773 @default.
- W2084741276 cites W2052988918 @default.
- W2084741276 cites W2073112515 @default.
- W2084741276 cites W2073563625 @default.
- W2084741276 cites W2079352395 @default.
- W2084741276 cites W2090344814 @default.
- W2084741276 cites W2094894663 @default.
- W2084741276 cites W2103446800 @default.
- W2084741276 cites W2167961748 @default.
- W2084741276 cites W2170625447 @default.
- W2084741276 cites W2171334332 @default.
- W2084741276 doi "https://doi.org/10.1016/s0731-7085(00)00271-5" @default.
- W2084741276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10898172" @default.
- W2084741276 hasPublicationYear "2000" @default.
- W2084741276 type Work @default.
- W2084741276 sameAs 2084741276 @default.
- W2084741276 citedByCount "49" @default.
- W2084741276 countsByYear W20847412762012 @default.
- W2084741276 countsByYear W20847412762013 @default.
- W2084741276 countsByYear W20847412762014 @default.
- W2084741276 countsByYear W20847412762015 @default.
- W2084741276 countsByYear W20847412762016 @default.
- W2084741276 countsByYear W20847412762017 @default.
- W2084741276 countsByYear W20847412762018 @default.
- W2084741276 countsByYear W20847412762019 @default.
- W2084741276 countsByYear W20847412762020 @default.
- W2084741276 countsByYear W20847412762021 @default.
- W2084741276 countsByYear W20847412762022 @default.
- W2084741276 crossrefType "journal-article" @default.
- W2084741276 hasAuthorship W2084741276A5015298982 @default.
- W2084741276 hasAuthorship W2084741276A5031921158 @default.
- W2084741276 hasAuthorship W2084741276A5081994437 @default.
- W2084741276 hasConcept C106289968 @default.
- W2084741276 hasConcept C119128265 @default.
- W2084741276 hasConcept C162356407 @default.
- W2084741276 hasConcept C179302884 @default.
- W2084741276 hasConcept C185592680 @default.
- W2084741276 hasConcept C205345274 @default.
- W2084741276 hasConcept C2776923573 @default.
- W2084741276 hasConcept C2777477808 @default.
- W2084741276 hasConcept C2780026642 @default.
- W2084741276 hasConcept C43617362 @default.
- W2084741276 hasConcept C55493867 @default.
- W2084741276 hasConceptScore W2084741276C106289968 @default.
- W2084741276 hasConceptScore W2084741276C119128265 @default.
- W2084741276 hasConceptScore W2084741276C162356407 @default.
- W2084741276 hasConceptScore W2084741276C179302884 @default.
- W2084741276 hasConceptScore W2084741276C185592680 @default.
- W2084741276 hasConceptScore W2084741276C205345274 @default.
- W2084741276 hasConceptScore W2084741276C2776923573 @default.
- W2084741276 hasConceptScore W2084741276C2777477808 @default.
- W2084741276 hasConceptScore W2084741276C2780026642 @default.
- W2084741276 hasConceptScore W2084741276C43617362 @default.
- W2084741276 hasConceptScore W2084741276C55493867 @default.
- W2084741276 hasIssue "1" @default.
- W2084741276 hasLocation W20847412761 @default.
- W2084741276 hasLocation W20847412762 @default.
- W2084741276 hasOpenAccess W2084741276 @default.
- W2084741276 hasPrimaryLocation W20847412761 @default.
- W2084741276 hasRelatedWork W1767355793 @default.
- W2084741276 hasRelatedWork W1850236418 @default.
- W2084741276 hasRelatedWork W1988364772 @default.
- W2084741276 hasRelatedWork W2033401628 @default.
- W2084741276 hasRelatedWork W2057766918 @default.
- W2084741276 hasRelatedWork W219495507 @default.
- W2084741276 hasRelatedWork W2315299911 @default.
- W2084741276 hasRelatedWork W2400127871 @default.
- W2084741276 hasRelatedWork W2978102718 @default.
- W2084741276 hasRelatedWork W2997529584 @default.
- W2084741276 hasVolume "23" @default.
- W2084741276 isParatext "false" @default.
- W2084741276 isRetracted "false" @default.
- W2084741276 magId "2084741276" @default.
- W2084741276 workType "article" @default.