Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084742840> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2084742840 endingPage "402" @default.
- W2084742840 startingPage "393" @default.
- W2084742840 abstract "Collagen and thrombin-activated (COAT) platelets represent a unique subset of activated platelets that exhibit high levels of several adhesive and procoagulant alpha-granule proteins on their surface. In this report we demonstrate that a similar subpopulation of platelets can also be generated by the combined stimulation of Fc gamma RIIA and thrombin receptors. Platelets activated in this manner are referred to as Fc receptor and thrombin-activated (FcRT) platelets, and they share many of the characteristics of the formerly observed COAT platelets, including aminophospholipid exposure, adhesive and procoagulant protein enrichment, increased frequency among young platelets, and sensitivity to transglutaminase inhibitors. Although Fc gamma RIIA receptor activation can be achieved either with anti-CD9 monoclonal antibodies (ALB-6 and ML-13) or with direct Fc receptor cross-linking, FcRT platelet generation occurs only with concurrent or slightly delayed thrombin stimulation. In fact, when thrombin was the second agonist, time delays of up to 120 seconds after Fc gamma RIIA receptor stimulation had little effect on the generation of FcRT platelets; however, a similar delay for convulxin plus thrombin activation results in a 90% diminution in COAT platelet production. FcRT platelet formation in platelet-poor plasma and whole blood was also investigated, and results were similar to those observed with gel-filtered platelets. Previous experiments with COAT platelet formation used physiologic agonists (collagen and thrombin) that might be encountered under either physiologic or pathologic conditions; however, the current experiments with Fc receptor stimulation offer the first example in which these highly prohemostatic platelets are likely to be strictly pathogenic." @default.
- W2084742840 created "2016-06-24" @default.
- W2084742840 creator A5050601486 @default.
- W2084742840 creator A5068359657 @default.
- W2084742840 date "2001-12-01" @default.
- W2084742840 modified "2023-10-16" @default.
- W2084742840 title "Simultaneous engagement of thrombin and FcγRIIA receptors results in platelets expressing high levels of procoagulant proteins" @default.
- W2084742840 cites W139961827 @default.
- W2084742840 cites W1540375091 @default.
- W2084742840 cites W1982435358 @default.
- W2084742840 cites W1984256286 @default.
- W2084742840 cites W1986451781 @default.
- W2084742840 cites W1990232178 @default.
- W2084742840 cites W2003713062 @default.
- W2084742840 cites W2029004784 @default.
- W2084742840 cites W2038993690 @default.
- W2084742840 cites W2044922012 @default.
- W2084742840 cites W2068747852 @default.
- W2084742840 cites W2073966706 @default.
- W2084742840 cites W2086823604 @default.
- W2084742840 cites W2159800908 @default.
- W2084742840 cites W2165178980 @default.
- W2084742840 cites W2220737842 @default.
- W2084742840 cites W2396385786 @default.
- W2084742840 cites W2396983430 @default.
- W2084742840 cites W2414595006 @default.
- W2084742840 cites W2417896506 @default.
- W2084742840 cites W4322702227 @default.
- W2084742840 doi "https://doi.org/10.1067/mlc.2001.120049" @default.
- W2084742840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11753286" @default.
- W2084742840 hasPublicationYear "2001" @default.
- W2084742840 type Work @default.
- W2084742840 sameAs 2084742840 @default.
- W2084742840 citedByCount "33" @default.
- W2084742840 countsByYear W20847428402012 @default.
- W2084742840 countsByYear W20847428402013 @default.
- W2084742840 countsByYear W20847428402015 @default.
- W2084742840 countsByYear W20847428402016 @default.
- W2084742840 countsByYear W20847428402017 @default.
- W2084742840 countsByYear W20847428402019 @default.
- W2084742840 countsByYear W20847428402020 @default.
- W2084742840 countsByYear W20847428402021 @default.
- W2084742840 countsByYear W20847428402022 @default.
- W2084742840 countsByYear W20847428402023 @default.
- W2084742840 crossrefType "journal-article" @default.
- W2084742840 hasAuthorship W2084742840A5050601486 @default.
- W2084742840 hasAuthorship W2084742840A5068359657 @default.
- W2084742840 hasConcept C126322002 @default.
- W2084742840 hasConcept C134018914 @default.
- W2084742840 hasConcept C149577978 @default.
- W2084742840 hasConcept C170493617 @default.
- W2084742840 hasConcept C185592680 @default.
- W2084742840 hasConcept C203014093 @default.
- W2084742840 hasConcept C24998067 @default.
- W2084742840 hasConcept C2777292125 @default.
- W2084742840 hasConcept C2778886182 @default.
- W2084742840 hasConcept C2778938600 @default.
- W2084742840 hasConcept C3018697912 @default.
- W2084742840 hasConcept C55493867 @default.
- W2084742840 hasConcept C71924100 @default.
- W2084742840 hasConcept C86803240 @default.
- W2084742840 hasConcept C89560881 @default.
- W2084742840 hasConceptScore W2084742840C126322002 @default.
- W2084742840 hasConceptScore W2084742840C134018914 @default.
- W2084742840 hasConceptScore W2084742840C149577978 @default.
- W2084742840 hasConceptScore W2084742840C170493617 @default.
- W2084742840 hasConceptScore W2084742840C185592680 @default.
- W2084742840 hasConceptScore W2084742840C203014093 @default.
- W2084742840 hasConceptScore W2084742840C24998067 @default.
- W2084742840 hasConceptScore W2084742840C2777292125 @default.
- W2084742840 hasConceptScore W2084742840C2778886182 @default.
- W2084742840 hasConceptScore W2084742840C2778938600 @default.
- W2084742840 hasConceptScore W2084742840C3018697912 @default.
- W2084742840 hasConceptScore W2084742840C55493867 @default.
- W2084742840 hasConceptScore W2084742840C71924100 @default.
- W2084742840 hasConceptScore W2084742840C86803240 @default.
- W2084742840 hasConceptScore W2084742840C89560881 @default.
- W2084742840 hasIssue "6" @default.
- W2084742840 hasLocation W20847428401 @default.
- W2084742840 hasLocation W20847428402 @default.
- W2084742840 hasOpenAccess W2084742840 @default.
- W2084742840 hasPrimaryLocation W20847428401 @default.
- W2084742840 hasRelatedWork W124575618 @default.
- W2084742840 hasRelatedWork W149121501 @default.
- W2084742840 hasRelatedWork W1999403270 @default.
- W2084742840 hasRelatedWork W2037076708 @default.
- W2084742840 hasRelatedWork W2084742840 @default.
- W2084742840 hasRelatedWork W2091112630 @default.
- W2084742840 hasRelatedWork W2096686021 @default.
- W2084742840 hasRelatedWork W2115629785 @default.
- W2084742840 hasRelatedWork W2204279058 @default.
- W2084742840 hasRelatedWork W2463317919 @default.
- W2084742840 hasVolume "138" @default.
- W2084742840 isParatext "false" @default.
- W2084742840 isRetracted "false" @default.
- W2084742840 magId "2084742840" @default.
- W2084742840 workType "article" @default.