FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084751180> ?p ?o ?g. }

• W2084751180 endingPage "433" @default.
• W2084751180 startingPage "433" @default.
• W2084751180 abstract "Mammalian cells are extremely sensitive to gamma rays at mitosis, the time at which their chromatin is maximally condensed. The radiation-induced killing of mitotic cells is well described by single-hit inactivation kinetics. To investigate if radiation hypersensitivity by single-hit inactivation correlated with chromatin condensation, Chinese hamster ovary (CHO) K1 (wild-type) and xrs-5 (radiosensitive mutant) cells were synchronized by mitotic shake-off procedures and the densities of their chromatin cross sections and their radiosensitivities were measured immediately and 2 h into G1 phase. The chromatin of G1-phase CHO K1 cells was dispersed uniformly throughout their nuclei, and its average density was at least three times less than in the chromosomes of mitotic CHO K1 cells. The alpha-inactivation co-efficient of mitotic CHO K1 cells was approximately 2.0 Gy(-1) and decreased approximately 10-fold when cells entered G1 phase. The density of chromatin in CHO xrs-5 cell chromosomes at mitosis was greater than in CHO K1 cell chromosomes, and the radiosensitivity of mitotic CHO xrs-5 cells was the greatest with alpha = 5.1 Gy(-1). In G1 phase, CHO xrs-5 cells were slightly more resistant to radiation than when in mitosis, but a significant proportion of their chromatin was found to remain in condensed form adjacent to the nuclear membrane. These studies indicate that in addition to their known defects in DNA repair and V(D)J recombination, CHO xrs-5 cells may also be defective in some process associated with the condensation and/or dispersion of chromatin at mitosis. Their radiation hypersensitivity could result, in part, from their DNA remaining in compacted form during interphase. The condensation status of DNA in other mammalian cells could define their intrinsic radiosensitivity by single-hit inactivation, the mechanism of cell killing which dominates at the dose fraction size (1.8-2.0 Gy) most commonly used in radiotherapy." @default.
• W2084751180 created "2016-06-24" @default.
• W2084751180 creator A5030816608 @default.
• W2084751180 creator A5062406672 @default.
• W2084751180 creator A5070721855 @default.
• W2084751180 creator A5071015857 @default.
• W2084751180 creator A5078010922 @default.
• W2084751180 creator A5084689683 @default.
• W2084751180 creator A5085022080 @default.
• W2084751180 date "1999-04-01" @default.
• W2084751180 modified "2023-09-26" @default.
• W2084751180 title "Condensed Chromatin and Cell Inactivation by Single-Hit Kinetics" @default.
• W2084751180 cites W1917341586 @default.
• W2084751180 cites W195460277 @default.
• W2084751180 cites W1965242104 @default.
• W2084751180 cites W1973053643 @default.
• W2084751180 cites W1976400042 @default.
• W2084751180 cites W1976729724 @default.
• W2084751180 cites W1977639464 @default.
• W2084751180 cites W1986965946 @default.
• W2084751180 cites W1987850577 @default.
• W2084751180 cites W1990942802 @default.
• W2084751180 cites W1998475589 @default.
• W2084751180 cites W2003125579 @default.
• W2084751180 cites W2012888776 @default.
• W2084751180 cites W2019963243 @default.
• W2084751180 cites W2023676537 @default.
• W2084751180 cites W2025823605 @default.
• W2084751180 cites W2032335736 @default.
• W2084751180 cites W2034353458 @default.
• W2084751180 cites W2039526816 @default.
• W2084751180 cites W2042726154 @default.
• W2084751180 cites W2046008851 @default.
• W2084751180 cites W2051202148 @default.
• W2084751180 cites W2057980517 @default.
• W2084751180 cites W2061223034 @default.
• W2084751180 cites W2066299923 @default.
• W2084751180 cites W2071387709 @default.
• W2084751180 cites W2071850617 @default.
• W2084751180 cites W2072720547 @default.
• W2084751180 cites W2079966048 @default.
• W2084751180 cites W2085302812 @default.
• W2084751180 cites W2088561350 @default.
• W2084751180 cites W2107635648 @default.
• W2084751180 cites W2147366348 @default.
• W2084751180 cites W2147850446 @default.
• W2084751180 cites W2149884878 @default.
• W2084751180 cites W2154981196 @default.
• W2084751180 cites W2167955466 @default.
• W2084751180 cites W2210872362 @default.
• W2084751180 cites W2318222641 @default.
• W2084751180 cites W2318912668 @default.
• W2084751180 cites W2320237600 @default.
• W2084751180 cites W2325162340 @default.
• W2084751180 cites W2333018166 @default.
• W2084751180 cites W2334018569 @default.
• W2084751180 cites W3213325150 @default.
• W2084751180 cites W621019215 @default.
• W2084751180 cites W2047885070 @default.
• W2084751180 doi "https://doi.org/10.2307/3579830" @default.
• W2084751180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10190495" @default.
• W2084751180 hasPublicationYear "1999" @default.
• W2084751180 type Work @default.
• W2084751180 sameAs 2084751180 @default.
• W2084751180 citedByCount "37" @default.
• W2084751180 countsByYear W20847511802012 @default.
• W2084751180 countsByYear W20847511802013 @default.
• W2084751180 countsByYear W20847511802015 @default.
• W2084751180 countsByYear W20847511802016 @default.
• W2084751180 countsByYear W20847511802017 @default.
• W2084751180 countsByYear W20847511802020 @default.
• W2084751180 crossrefType "journal-article" @default.
• W2084751180 hasAuthorship W2084751180A5030816608 @default.
• W2084751180 hasAuthorship W2084751180A5062406672 @default.
• W2084751180 hasAuthorship W2084751180A5070721855 @default.
• W2084751180 hasAuthorship W2084751180A5071015857 @default.
• W2084751180 hasAuthorship W2084751180A5078010922 @default.
• W2084751180 hasAuthorship W2084751180A5084689683 @default.
• W2084751180 hasAuthorship W2084751180A5085022080 @default.
• W2084751180 hasConcept C104317684 @default.
• W2084751180 hasConcept C111337013 @default.
• W2084751180 hasConcept C121332964 @default.
• W2084751180 hasConcept C12554922 @default.
• W2084751180 hasConcept C148196450 @default.
• W2084751180 hasConcept C153911025 @default.
• W2084751180 hasConcept C175656101 @default.
• W2084751180 hasConcept C178108356 @default.
• W2084751180 hasConcept C185544564 @default.
• W2084751180 hasConcept C185592680 @default.
• W2084751180 hasConcept C206684579 @default.
• W2084751180 hasConcept C45413362 @default.
• W2084751180 hasConcept C54355233 @default.
• W2084751180 hasConcept C552990157 @default.
• W2084751180 hasConcept C81885089 @default.
• W2084751180 hasConcept C83640560 @default.
• W2084751180 hasConcept C86803240 @default.
• W2084751180 hasConcept C93304396 @default.
• W2084751180 hasConcept C95444343 @default.

• next