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• W2084758592 abstract "It is now recognized that the tumor microenvironment creates a protective neo-tissue that isolates the tumor from the various defense strategies of the body. Evidence demonstrates that, with successive therapeutic attempts, cancer cells acquire resistance to individual treatment modalities. For example, exposure to cytotoxic drugs results in the survival of approximately 20-30% of the cancer cells as only dividing cells succumb to each toxic exposure. With follow-up treatments, each additional dose results in tumor-associated fibroblasts secreting surface-protective proteins, which enhance cancer cell resistance. Similar outcomes are reported following radiotherapy. These defensive strategies are indicative of evolved capabilities of cancer to assure successful tumor growth through well-established anti-tumor-protective adaptations. As such, successful cancer management requires the activation of multiple cellular 'kill switches' to prevent initiation of diverse protective adaptations. Thermal therapies are unique treatment modalities typically applied as monotherapies (without repetition) thereby denying cancer cells the opportunity to express defensive mutations. Further, the destructive mechanisms of action involved with cryoablation (CA) include both physical and molecular insults resulting in the disruption of multiple defensive strategies that are not cell cycle dependent and adds a damaging structural (physical) element. This review discusses the application and clinical outcomes of CA with an emphasis on the mechanisms of cell death induced by structural, metabolic, vascular and immune processes. The induction of diverse cell death cascades, resulting in the activation of apoptosis and necrosis, allows CA to be characterized as a combinatorial treatment modality. Our understanding of these mechanisms now supports adjunctive therapies that can augment cell death pathways." @default.
• W2084758592 created "2016-06-24" @default.
• W2084758592 creator A5003043118 @default.
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• W2084758592 creator A5045309865 @default.
• W2084758592 creator A5054837196 @default.
• W2084758592 creator A5075980195 @default.
• W2084758592 date "2015-01-27" @default.
• W2084758592 modified "2023-10-18" @default.
• W2084758592 title "Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue" @default.
• W2084758592 cites W1487210925 @default.
• W2084758592 cites W1489965053 @default.
• W2084758592 cites W1490795708 @default.
• W2084758592 cites W1534849470 @default.
• W2084758592 cites W1835248769 @default.
• W2084758592 cites W1925266730 @default.
• W2084758592 cites W1963635847 @default.
• W2084758592 cites W1964989417 @default.
• W2084758592 cites W1966046861 @default.
• W2084758592 cites W1967256542 @default.
• W2084758592 cites W1972943074 @default.
• W2084758592 cites W1975211715 @default.
• W2084758592 cites W1976050890 @default.
• W2084758592 cites W1980896156 @default.
• W2084758592 cites W1982003465 @default.
• W2084758592 cites W1983111363 @default.
• W2084758592 cites W1983615147 @default.
• W2084758592 cites W1983624489 @default.
• W2084758592 cites W1984689348 @default.
• W2084758592 cites W1985256611 @default.
• W2084758592 cites W1985549756 @default.
• W2084758592 cites W1985763519 @default.
• W2084758592 cites W1988210408 @default.
• W2084758592 cites W1991755279 @default.
• W2084758592 cites W1996052186 @default.
• W2084758592 cites W1996480534 @default.
• W2084758592 cites W1998909064 @default.
• W2084758592 cites W1999657696 @default.
• W2084758592 cites W2000299716 @default.
• W2084758592 cites W2003397061 @default.
• W2084758592 cites W2006367870 @default.
• W2084758592 cites W2007199759 @default.
• W2084758592 cites W2009886857 @default.
• W2084758592 cites W2012070204 @default.
• W2084758592 cites W2013971175 @default.
• W2084758592 cites W2021523443 @default.
• W2084758592 cites W2025055937 @default.
• W2084758592 cites W2025094014 @default.
• W2084758592 cites W2026216143 @default.
• W2084758592 cites W2028098481 @default.
• W2084758592 cites W2029628302 @default.
• W2084758592 cites W2030103235 @default.
• W2084758592 cites W2030694165 @default.
• W2084758592 cites W2032701002 @default.
• W2084758592 cites W2038065677 @default.
• W2084758592 cites W2040263267 @default.
• W2084758592 cites W2042669918 @default.
• W2084758592 cites W2043175101 @default.
• W2084758592 cites W2046839370 @default.
• W2084758592 cites W2047307513 @default.
• W2084758592 cites W2049440043 @default.
• W2084758592 cites W2053579882 @default.
• W2084758592 cites W2054160526 @default.
• W2084758592 cites W2054884203 @default.
• W2084758592 cites W2054983250 @default.
• W2084758592 cites W2058803724 @default.
• W2084758592 cites W2062817759 @default.
• W2084758592 cites W2064665989 @default.
• W2084758592 cites W2065024030 @default.
• W2084758592 cites W2065332029 @default.
• W2084758592 cites W2070324190 @default.
• W2084758592 cites W2071795825 @default.
• W2084758592 cites W2071970547 @default.
• W2084758592 cites W2071993487 @default.
• W2084758592 cites W2073531001 @default.
• W2084758592 cites W2073543664 @default.
• W2084758592 cites W2074144915 @default.
• W2084758592 cites W2076198692 @default.
• W2084758592 cites W2079033872 @default.
• W2084758592 cites W2080046326 @default.
• W2084758592 cites W2082823320 @default.
• W2084758592 cites W2091424183 @default.
• W2084758592 cites W2093867637 @default.
• W2084758592 cites W2098793684 @default.
• W2084758592 cites W2101246186 @default.
• W2084758592 cites W2101817861 @default.
• W2084758592 cites W2105386786 @default.
• W2084758592 cites W2105699441 @default.
• W2084758592 cites W2116220875 @default.
• W2084758592 cites W2117692326 @default.
• W2084758592 cites W2131779232 @default.
• W2084758592 cites W2135410692 @default.
• W2084758592 cites W2137611824 @default.
• W2084758592 cites W2142627274 @default.
• W2084758592 cites W2143252722 @default.
• W2084758592 cites W2150048195 @default.

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