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• W2084767046 abstract "Abstract To clear pathogens from host tissues or biomaterial surfaces, phagocytes have to break the adhesive bacteria-substrate interactions. Here we analysed the mechanobiological process that enables macrophages to lift-off and phagocytose surface-bound Escherichia coli ( E. coli ). In this opsonin-independent process, macrophage filopodia hold on to the E. coli fimbriae long enough to induce a local protrusion of a lamellipodium. Specific contacts between the macrophage and E. coli are formed via the glycoprotein CD48 on filopodia and the adhesin FimH on type 1 fimbriae (hook). We show that bacterial detachment from surfaces occurrs after a lamellipodium has protruded underneath the bacterium (shovel), thereby breaking the multiple bacterium-surface interactions. After lift-off, the bacterium is engulfed by a phagocytic cup. Force activated catch bonds enable the long-term survival of the filopodium-fimbrium interactions while soluble mannose inhibitors and CD48 antibodies suppress the contact formation and thereby inhibit subsequent E. coli phagocytosis." @default.
• W2084767046 created "2016-06-24" @default.
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• W2084767046 date "2013-10-07" @default.
• W2084767046 modified "2023-10-03" @default.
• W2084767046 title "Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism" @default.
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• W2084767046 doi "https://doi.org/10.1038/srep02884" @default.
• W2084767046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3791455" @default.
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• W2084767046 hasPublicationYear "2013" @default.
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