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• W2084775687 abstract "Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects." @default.
• W2084775687 created "2016-06-24" @default.
• W2084775687 creator A5058783930 @default.
• W2084775687 date "1996-07-01" @default.
• W2084775687 modified "2023-09-27" @default.
• W2084775687 title "Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats" @default.
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• W2084775687 doi "https://doi.org/10.1016/0306-4530(96)00017-0" @default.
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