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• W2084787851 abstract "Heparin is a highly sulfated polysaccharide that serves biologically relevant roles as an anticoagulant and anticancer agent. While it is well-known that modification of heparin's sulfation pattern can drastically influence its ability to bind growth factors and other extracellular molecules, very little is known about the cellular uptake of heparin and the role sulfation patterns serve in affecting its internalization. In this study, we chemically synthesized several fluorescently labeled heparins consisting of a variety of sulfation patterns. These polysaccharides were thoroughly characterized using anion exchange chromatography and size exclusion chromatography. Subsequently, we utilized flow cytometry and confocal imaging to show that sulfation patterns differentially affect the amount of heparin uptake in multiple cell types. This study provides the first comprehensive analysis of the effect of sulfation pattern on the cellular internalization of heparin or heparan sulfate like polysaccharides. The results of this study expand current knowledge regarding heparin internalization and provide insights into developing more effective heparin-based drug conjugates for applications in intracellular drug delivery." @default.
• W2084787851 created "2016-06-24" @default.
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• W2084787851 date "2013-02-27" @default.
• W2084787851 modified "2023-10-16" @default.
• W2084787851 title "Sulfation Patterns Determine Cellular Internalization of Heparin-Like Polysaccharides" @default.
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• W2084787851 doi "https://doi.org/10.1021/mp300679a" @default.
• W2084787851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3685167" @default.
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