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• W2084790472 abstract "We have investigated the expression patterns of a basic helix–loop–helix regulatory gene,neuroD,in primary cultures of murine cerebral cortical neurons. The differentiation states of neurons in primary cultures were determined by the sensitivity of neurons to glutamate toxicity and the expression of specific proteins such as the phosphorylated form of a 200-kDa neurofilament, HPC-1/syntaxin 1A, and cell adhesion molecule L1. The expression of neuroD was determined by RT-PCR analysis andin situhybridization. The experimental results thus obtained revealed that neuronal maturation is initiated between Day 7 and Day 11 in the culture as already known, and that the expression of neuroD decreases with increasing days in culture. Based on these findings, it was concluded that neuroD is expressed in immature neurons but not in mature ones." @default.
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• W2084790472 date "1997-11-01" @default.
• W2084790472 modified "2023-10-16" @default.
• W2084790472 title "Differential Expression of NeuroD in Primary Cultures of Cerebral Cortical Neurons" @default.
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• W2084790472 doi "https://doi.org/10.1006/excr.1997.3757" @default.
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