FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084793886> ?p ?o ?g. }

• W2084793886 endingPage "930" @default.
• W2084793886 startingPage "925" @default.
• W2084793886 abstract "The influence of insulin binding antibodies on the pharmacokinetics of NPH insulin was studied in Type 1 diabetic patients on human insulin. Insulin-antibody binding (B(o) was measured during a screening procedure in 155 Type 1 diabetic patients. In 36 patients, B(o) was < 1.5%, and in 38 patients B(o) was > 10.0%. Of these, 6 patients, group 1 (B(o) < 1.5%) and 8 patients, group 2 (B(o) > 10.0%), respectively, subsequently participated in a pharmacokinetic study. Free insulin and the glucose infusion rate were measured using a euglycaemic clamp after subcutaneous injection of NPH insulin (0.4 U kg-1). The areas under the curve (AUC) of free insulin concentration were smaller for group 2 (p = 0.01) than for group 1 (212.2 +/- 22.0 vs 316.8 +/- 25.3 mU l-1h). The AUCs of the glucose infusion rate were also smaller for group 2 (p < 0.05) than for group 1 (2.50 +/- 0.32 vs 3.58 +/- 0.36 g kg-1). A significant negative correlation exists between the AUCs for free insulin concentration and insulin-antibody binding B(o) (r = 0.76, p = 0.001). The daily insulin dosage was higher in group 2 (p = 0.02) than in group 1 (0.66 +/- 0.03 vs 0.53 +/- 0.03 U kg-1). We conclude that insulin antibodies influence the pharmacokinetics of NPH human insulin. The demonstrable influence on the kinetics of free insulin and glucose utilization leads to a slight increase in daily total insulin requirements." @default.
• W2084793886 created "2016-06-24" @default.
• W2084793886 creator A5008969604 @default.
• W2084793886 creator A5015782926 @default.
• W2084793886 creator A5033738832 @default.
• W2084793886 creator A5051852395 @default.
• W2084793886 creator A5085032333 @default.
• W2084793886 date "1995-10-01" @default.
• W2084793886 modified "2023-09-23" @default.
• W2084793886 title "The Influence of Insulin Antibodies on the Pharmacokinetics of NPH Insulin in Patients with Type 1 Diabetes treated with Human Insulin" @default.
• W2084793886 cites W1860468106 @default.
• W2084793886 cites W1980147239 @default.
• W2084793886 cites W1994016083 @default.
• W2084793886 cites W2003022604 @default.
• W2084793886 cites W2006057295 @default.
• W2084793886 cites W2016954346 @default.
• W2084793886 cites W2019136020 @default.
• W2084793886 cites W2020266464 @default.
• W2084793886 cites W2029813765 @default.
• W2084793886 cites W2032579577 @default.
• W2084793886 cites W2037427263 @default.
• W2084793886 cites W2040746407 @default.
• W2084793886 cites W2042314257 @default.
• W2084793886 cites W2043813981 @default.
• W2084793886 cites W2060455085 @default.
• W2084793886 cites W2066999452 @default.
• W2084793886 cites W2068252820 @default.
• W2084793886 cites W2079170821 @default.
• W2084793886 cites W2080304254 @default.
• W2084793886 cites W2091030955 @default.
• W2084793886 cites W2104564587 @default.
• W2084793886 cites W2106702280 @default.
• W2084793886 cites W2119891717 @default.
• W2084793886 cites W2123183354 @default.
• W2084793886 cites W2171170795 @default.
• W2084793886 cites W2319764155 @default.
• W2084793886 cites W2416217633 @default.
• W2084793886 cites W2053632293 @default.
• W2084793886 doi "https://doi.org/10.1111/j.1464-5491.1995.tb00398.x" @default.
• W2084793886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8846686" @default.
• W2084793886 hasPublicationYear "1995" @default.
• W2084793886 type Work @default.
• W2084793886 sameAs 2084793886 @default.
• W2084793886 citedByCount "28" @default.
• W2084793886 countsByYear W20847938862012 @default.
• W2084793886 countsByYear W20847938862013 @default.
• W2084793886 countsByYear W20847938862014 @default.
• W2084793886 countsByYear W20847938862015 @default.
• W2084793886 countsByYear W20847938862017 @default.
• W2084793886 countsByYear W20847938862023 @default.
• W2084793886 crossrefType "journal-article" @default.
• W2084793886 hasAuthorship W2084793886A5008969604 @default.
• W2084793886 hasAuthorship W2084793886A5015782926 @default.
• W2084793886 hasAuthorship W2084793886A5033738832 @default.
• W2084793886 hasAuthorship W2084793886A5051852395 @default.
• W2084793886 hasAuthorship W2084793886A5085032333 @default.
• W2084793886 hasConcept C112705442 @default.
• W2084793886 hasConcept C126322002 @default.
• W2084793886 hasConcept C134018914 @default.
• W2084793886 hasConcept C159654299 @default.
• W2084793886 hasConcept C203014093 @default.
• W2084793886 hasConcept C2777180221 @default.
• W2084793886 hasConcept C2778804033 @default.
• W2084793886 hasConcept C2779306644 @default.
• W2084793886 hasConcept C2779920387 @default.
• W2084793886 hasConcept C2780668416 @default.
• W2084793886 hasConcept C3019948211 @default.
• W2084793886 hasConcept C555293320 @default.
• W2084793886 hasConcept C71924100 @default.
• W2084793886 hasConceptScore W2084793886C112705442 @default.
• W2084793886 hasConceptScore W2084793886C126322002 @default.
• W2084793886 hasConceptScore W2084793886C134018914 @default.
• W2084793886 hasConceptScore W2084793886C159654299 @default.
• W2084793886 hasConceptScore W2084793886C203014093 @default.
• W2084793886 hasConceptScore W2084793886C2777180221 @default.
• W2084793886 hasConceptScore W2084793886C2778804033 @default.
• W2084793886 hasConceptScore W2084793886C2779306644 @default.
• W2084793886 hasConceptScore W2084793886C2779920387 @default.
• W2084793886 hasConceptScore W2084793886C2780668416 @default.
• W2084793886 hasConceptScore W2084793886C3019948211 @default.
• W2084793886 hasConceptScore W2084793886C555293320 @default.
• W2084793886 hasConceptScore W2084793886C71924100 @default.
• W2084793886 hasIssue "10" @default.
• W2084793886 hasLocation W20847938861 @default.
• W2084793886 hasLocation W20847938862 @default.
• W2084793886 hasOpenAccess W2084793886 @default.
• W2084793886 hasPrimaryLocation W20847938861 @default.
• W2084793886 hasRelatedWork W1983641721 @default.
• W2084793886 hasRelatedWork W1995945960 @default.
• W2084793886 hasRelatedWork W2026226896 @default.
• W2084793886 hasRelatedWork W2032033851 @default.
• W2084793886 hasRelatedWork W2041678535 @default.
• W2084793886 hasRelatedWork W2066345847 @default.
• W2084793886 hasRelatedWork W2089387278 @default.
• W2084793886 hasRelatedWork W2095179743 @default.
• W2084793886 hasRelatedWork W2130904138 @default.
• W2084793886 hasRelatedWork W4230655895 @default.
• W2084793886 hasVolume "12" @default.

• next