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• W2084804122 abstract "<h3>Objective</h3> To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. <h3>Setting</h3> Six neonatal intensive care units (NICUs). <h3>Patients</h3> 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. <h3>Main outcome measures</h3> Positive and negative predictive values at different PCT cut-off levels. <h3>Results</h3> The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. <h3>Conclusions</h3> In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS." @default.
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• W2084804122 date "2012-08-29" @default.
• W2084804122 modified "2023-10-14" @default.
• W2084804122 title "Procalcitonin in detecting neonatal nosocomial sepsis" @default.
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• W2084804122 doi "https://doi.org/10.1136/fetalneonatal-2010-194100" @default.
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