Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084807245> ?p ?o ?g. }
- W2084807245 endingPage "126" @default.
- W2084807245 startingPage "119" @default.
- W2084807245 abstract "αvβ3 integrin has been reported as a promising therapeutic target for angiogenesis. In the present study, we tested the antiangiogenic activity of 3-[3-(6-guanidino-1-oxoisoindolin-2-yl) propanamido]-3-(pyridin-3-yl) propanoic acid dihydrochloride (GOPPP), a novel non-peptide αvβ3 antagonist. Both human umbilical vein endothelial cells (HUVECs) and a mouse model of oxygen-induced retinopathy (OIR) were investigated separately. HUVEC adhesion, proliferation, migration, ERK1/2 and Akt phosphorylation were assessed. C57BL/6 mice were used for the studies in the OIR model. After exposure to 75% oxygen from postnatal day (PD) 7 to PD12, the mice were returned to room air, and GOPPP was intravitreally administered on PD12. Retinal neovascularization was evaluated on PD17. Hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) protein levels and ERK1/2 phosphorylation were determined by Western blot analysis of retina proteins. GOPPP significantly inhibited the pro-angiogenic effects of vitronectin on HUVECs, including adhesion, proliferation, and migration, and inhibited ERK1/2 and Akt phosphorylation. Retinal neovascularization in the OIR model was significantly suppressed by intravitreal administration of 50 ng GOPPP. The pro-angiogenic factors HIF-1α and VEGF induced by hypoxia were significantly inhibited by GOPPP in OIR mice. GOPPP administration also inhibited ERK1/2 phosphorylation in the OIR model. These results indicate that GOPPP, a novel αvβ3 integrin antagonist, may have potential for the treatment of pathological retinal angiogenesis." @default.
- W2084807245 created "2016-06-24" @default.
- W2084807245 creator A5011090751 @default.
- W2084807245 creator A5023355985 @default.
- W2084807245 creator A5033911461 @default.
- W2084807245 creator A5041816063 @default.
- W2084807245 creator A5052484642 @default.
- W2084807245 creator A5081209883 @default.
- W2084807245 creator A5083729859 @default.
- W2084807245 date "2014-12-01" @default.
- W2084807245 modified "2023-09-25" @default.
- W2084807245 title "Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice" @default.
- W2084807245 cites W1896287540 @default.
- W2084807245 cites W1956645860 @default.
- W2084807245 cites W1967280822 @default.
- W2084807245 cites W1967348819 @default.
- W2084807245 cites W1973197740 @default.
- W2084807245 cites W1974777081 @default.
- W2084807245 cites W1974810323 @default.
- W2084807245 cites W1980837668 @default.
- W2084807245 cites W1986827117 @default.
- W2084807245 cites W1987074112 @default.
- W2084807245 cites W1993033290 @default.
- W2084807245 cites W2001753204 @default.
- W2084807245 cites W2012998128 @default.
- W2084807245 cites W2016517388 @default.
- W2084807245 cites W2019047953 @default.
- W2084807245 cites W2028691987 @default.
- W2084807245 cites W2029398151 @default.
- W2084807245 cites W2035572527 @default.
- W2084807245 cites W2046440184 @default.
- W2084807245 cites W2057775160 @default.
- W2084807245 cites W2061326367 @default.
- W2084807245 cites W2073962302 @default.
- W2084807245 cites W2083637184 @default.
- W2084807245 cites W2088037057 @default.
- W2084807245 cites W2088436995 @default.
- W2084807245 cites W2100363932 @default.
- W2084807245 cites W2108059110 @default.
- W2084807245 cites W2111444803 @default.
- W2084807245 cites W2113267611 @default.
- W2084807245 cites W2116063661 @default.
- W2084807245 cites W2124156250 @default.
- W2084807245 cites W2127372364 @default.
- W2084807245 cites W2137893922 @default.
- W2084807245 cites W2138986195 @default.
- W2084807245 cites W2141816935 @default.
- W2084807245 cites W2143755436 @default.
- W2084807245 cites W2157603347 @default.
- W2084807245 cites W2161873278 @default.
- W2084807245 cites W2164899193 @default.
- W2084807245 cites W2167107456 @default.
- W2084807245 cites W2168438265 @default.
- W2084807245 cites W2171767433 @default.
- W2084807245 cites W4243385699 @default.
- W2084807245 cites W87646094 @default.
- W2084807245 doi "https://doi.org/10.1016/j.exer.2014.11.004" @default.
- W2084807245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446322" @default.
- W2084807245 hasPublicationYear "2014" @default.
- W2084807245 type Work @default.
- W2084807245 sameAs 2084807245 @default.
- W2084807245 citedByCount "16" @default.
- W2084807245 countsByYear W20848072452015 @default.
- W2084807245 countsByYear W20848072452016 @default.
- W2084807245 countsByYear W20848072452017 @default.
- W2084807245 countsByYear W20848072452018 @default.
- W2084807245 countsByYear W20848072452019 @default.
- W2084807245 countsByYear W20848072452020 @default.
- W2084807245 countsByYear W20848072452021 @default.
- W2084807245 countsByYear W20848072452022 @default.
- W2084807245 countsByYear W20848072452023 @default.
- W2084807245 crossrefType "journal-article" @default.
- W2084807245 hasAuthorship W2084807245A5011090751 @default.
- W2084807245 hasAuthorship W2084807245A5023355985 @default.
- W2084807245 hasAuthorship W2084807245A5033911461 @default.
- W2084807245 hasAuthorship W2084807245A5041816063 @default.
- W2084807245 hasAuthorship W2084807245A5052484642 @default.
- W2084807245 hasAuthorship W2084807245A5081209883 @default.
- W2084807245 hasAuthorship W2084807245A5083729859 @default.
- W2084807245 hasConcept C11960822 @default.
- W2084807245 hasConcept C126322002 @default.
- W2084807245 hasConcept C134018914 @default.
- W2084807245 hasConcept C146285616 @default.
- W2084807245 hasConcept C167734588 @default.
- W2084807245 hasConcept C170493617 @default.
- W2084807245 hasConcept C185592680 @default.
- W2084807245 hasConcept C195687474 @default.
- W2084807245 hasConcept C202751555 @default.
- W2084807245 hasConcept C2777025900 @default.
- W2084807245 hasConcept C2777411675 @default.
- W2084807245 hasConcept C2777844972 @default.
- W2084807245 hasConcept C2778271429 @default.
- W2084807245 hasConcept C2780394083 @default.
- W2084807245 hasConcept C2780827179 @default.
- W2084807245 hasConcept C502942594 @default.
- W2084807245 hasConcept C55493867 @default.
- W2084807245 hasConcept C71924100 @default.
- W2084807245 hasConcept C75217442 @default.