FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084808214> ?p ?o ?g. }

• W2084808214 endingPage "307" @default.
• W2084808214 startingPage "291" @default.
• W2084808214 abstract "Metabotropic gamma-aminobutyric acid receptors (GABA(B)Rs) are involved in modulation of synaptic transmission and activity of cerebellar and thalamic neurons. We used subtype-specific antibodies in pre- and postembedding immunohistochemistry combined with three-dimensional reconstruction of labelled profiles and quantification of immunoparticles to reveal the subcellular distribution of pre- and postsynaptic GABA(B)R1a/b and GABA(B)R2 in the rat cerebellum and ventrobasal thalamus. GABA(B)R1a/b and R2 were extensively colocalized in most brain regions including the cerebellum and thalamus. In the cerebellum, immunoreactivity for both subtypes was prevalent in the molecular layer. The most intense immunoreactivity was found in Purkinje cell spines with a high density of immunoparticles at extrasynaptic sites peaking at around 240 nm from glutamatergic synapses between spines and parallel fibre varicosities. This is in contrast to dendrites at sites around GABAergic synapses where sparse and random distribution was found for both subtypes. In addition, more than one-tenth of the synaptic membrane specialization of spine-parallel fibre synapses were labelled at pre- or postsynaptic sites. Weak immunolabelling for both subtypes was also seen in parallel fibres but only rarely in GABAergic axons. In the ventrobasal thalamus, immunolabelling for both receptor subtypes was intense over the dendritic field of thalamocortical cells. Electron microscopy demonstrated an extrasynaptic localization of GABA(B)R1a/b and R2 exclusively in postsynaptic elements. Quantitative analysis further revealed the density of GABA(B)R1a/b around GABAergic synapses was higher than glutamatergic synapses on thalamocortical cell dendrites. The distinct localization of GABA(B)Rs relative to synaptic sites in the cerebellum and ventrobasal thalamus suggests that GABA(B)Rs differentially regulate activity of different neuronal populations." @default.
• W2084808214 created "2016-06-24" @default.
• W2084808214 creator A5034338074 @default.
• W2084808214 creator A5039231233 @default.
• W2084808214 creator A5040533199 @default.
• W2084808214 creator A5043182830 @default.
• W2084808214 creator A5050849790 @default.
• W2084808214 creator A5076381637 @default.
• W2084808214 creator A5090010687 @default.
• W2084808214 date "2002-01-01" @default.
• W2084808214 modified "2023-10-13" @default.
• W2084808214 title "Distinct localization of GABA_Breceptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus" @default.
• W2084808214 cites W1571586310 @default.
• W2084808214 cites W1571745125 @default.
• W2084808214 cites W1582986153 @default.
• W2084808214 cites W1598669426 @default.
• W2084808214 cites W1654156243 @default.
• W2084808214 cites W1762877386 @default.
• W2084808214 cites W1891269879 @default.
• W2084808214 cites W1964742037 @default.
• W2084808214 cites W1968059634 @default.
• W2084808214 cites W1979929840 @default.
• W2084808214 cites W1981763442 @default.
• W2084808214 cites W1985893094 @default.
• W2084808214 cites W1986584374 @default.
• W2084808214 cites W1986814377 @default.
• W2084808214 cites W1992679778 @default.
• W2084808214 cites W1993861337 @default.
• W2084808214 cites W1994520251 @default.
• W2084808214 cites W1994799682 @default.
• W2084808214 cites W1996486666 @default.
• W2084808214 cites W1997032972 @default.
• W2084808214 cites W1998116616 @default.
• W2084808214 cites W2000228875 @default.
• W2084808214 cites W2001747644 @default.
• W2084808214 cites W2003677450 @default.
• W2084808214 cites W2005096312 @default.
• W2084808214 cites W2014352371 @default.
• W2084808214 cites W2017482423 @default.
• W2084808214 cites W2020280632 @default.
• W2084808214 cites W2021083001 @default.
• W2084808214 cites W2024328209 @default.
• W2084808214 cites W2025669261 @default.
• W2084808214 cites W2028997551 @default.
• W2084808214 cites W2034789492 @default.
• W2084808214 cites W2035710317 @default.
• W2084808214 cites W2046893368 @default.
• W2084808214 cites W2047559557 @default.
• W2084808214 cites W2049240667 @default.
• W2084808214 cites W2052317533 @default.
• W2084808214 cites W2063812162 @default.
• W2084808214 cites W2065493990 @default.
• W2084808214 cites W2065843242 @default.
• W2084808214 cites W2065947284 @default.
• W2084808214 cites W2066991732 @default.
• W2084808214 cites W2067267876 @default.
• W2084808214 cites W2069397698 @default.
• W2084808214 cites W2071230662 @default.
• W2084808214 cites W2073248356 @default.
• W2084808214 cites W2079283223 @default.
• W2084808214 cites W2079311820 @default.
• W2084808214 cites W2083075722 @default.
• W2084808214 cites W2084240593 @default.
• W2084808214 cites W2086686009 @default.
• W2084808214 cites W2089809296 @default.
• W2084808214 cites W2090911265 @default.
• W2084808214 cites W2093098283 @default.
• W2084808214 cites W2103292884 @default.
• W2084808214 cites W2104311488 @default.
• W2084808214 cites W2105977945 @default.
• W2084808214 cites W2109746889 @default.
• W2084808214 cites W2110469184 @default.
• W2084808214 cites W2111421751 @default.
• W2084808214 cites W2125356699 @default.
• W2084808214 cites W2125795987 @default.
• W2084808214 cites W2128426029 @default.
• W2084808214 cites W2133336753 @default.
• W2084808214 cites W2142495170 @default.
• W2084808214 cites W2151683710 @default.
• W2084808214 cites W2154447884 @default.
• W2084808214 cites W2160483038 @default.
• W2084808214 cites W2163634461 @default.
• W2084808214 cites W2163660989 @default.
• W2084808214 cites W2165544326 @default.
• W2084808214 cites W2167767264 @default.
• W2084808214 cites W2414752865 @default.
• W2084808214 cites W4229627221 @default.
• W2084808214 cites W71834388 @default.
• W2084808214 doi "https://doi.org/10.1046/j.0953-816x.2001.01855.x" @default.
• W2084808214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11849296" @default.
• W2084808214 hasPublicationYear "2002" @default.
• W2084808214 type Work @default.
• W2084808214 sameAs 2084808214 @default.
• W2084808214 citedByCount "161" @default.
• W2084808214 countsByYear W20848082142012 @default.
• W2084808214 countsByYear W20848082142013 @default.
• W2084808214 countsByYear W20848082142014 @default.
• W2084808214 countsByYear W20848082142015 @default.

• next