Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084823895> ?p ?o ?g. }
- W2084823895 endingPage "618" @default.
- W2084823895 startingPage "614" @default.
- W2084823895 abstract "The aetiology of aortic aneurysms (AAs) is the subject of intense clinical investigation. One of the critical points in their pathogenesis is the disruption of the balance between vascular extracellular matrix deposition and degradation. AAs are common features in some genetically determined diseases of the connective tissue, such as Marfan and Loeys-Dietz Syndromes. Acquired factors determining an enhanced inflammatory state of the arterial wall also play a key role. Previous studies have determined the role of TGF-beta as the principal mediator of the pathogenesis of the alterations of the arterial wall homeostasis in aneurysms. The current medical management of any AA is mainly focused on the use of pharmacological agents that reduce hemodynamic stress of aortic wall, since hypertension is the major risk factor for the enlargement and rupture of the AAs. Thus, this approach is useful to reduce the risk of aneurysm rupture but is far from being a comprehensive pathophysiology-based therapeutic approach. Drugs with the potential of reducing the action of TGF-beta, which activation and expression has been reported to have a major role in the molecular pathogenesis of the aneurysms, improving matrix repair, decreasing the proteolytic pattern and inhibition of angiotensin converting enzyme as well as preventing angiotensin II-induced AT1R (angiotensin type 1 receptor) activation, can represent new options in the medical therapy of AAs. We propose that a combination of statins and PPAR-gamma agonist could be a useful adjunctive therapy in this condition. The new pathophysiology-based therapeutic approach, involving the pathological patterns and mechanisms leading to the rupture of the AAs, could represent an interesting additional tool in combination with the current established anti-hypertensive therapy." @default.
- W2084823895 created "2016-06-24" @default.
- W2084823895 creator A5035542322 @default.
- W2084823895 creator A5053802958 @default.
- W2084823895 date "2009-10-01" @default.
- W2084823895 modified "2023-10-01" @default.
- W2084823895 title "A combination of PPAR-γ agonists and HMG CoA reductase inhibitors (statins) as a new therapy for the conservative treatment of AAS (aortic aneurysm syndromes)" @default.
- W2084823895 cites W1586552615 @default.
- W2084823895 cites W1966346645 @default.
- W2084823895 cites W1966598111 @default.
- W2084823895 cites W1967965141 @default.
- W2084823895 cites W1969112793 @default.
- W2084823895 cites W1970779494 @default.
- W2084823895 cites W1976416423 @default.
- W2084823895 cites W1977004017 @default.
- W2084823895 cites W1977666051 @default.
- W2084823895 cites W1978169548 @default.
- W2084823895 cites W1984633752 @default.
- W2084823895 cites W1991456443 @default.
- W2084823895 cites W1993694317 @default.
- W2084823895 cites W1996232545 @default.
- W2084823895 cites W2010391385 @default.
- W2084823895 cites W2012409690 @default.
- W2084823895 cites W2015615071 @default.
- W2084823895 cites W2016211503 @default.
- W2084823895 cites W2021685843 @default.
- W2084823895 cites W2021758696 @default.
- W2084823895 cites W2023097850 @default.
- W2084823895 cites W2025657436 @default.
- W2084823895 cites W2030338284 @default.
- W2084823895 cites W2031667124 @default.
- W2084823895 cites W2033332566 @default.
- W2084823895 cites W2034937826 @default.
- W2084823895 cites W2037268380 @default.
- W2084823895 cites W2038136158 @default.
- W2084823895 cites W2038393500 @default.
- W2084823895 cites W2054351373 @default.
- W2084823895 cites W2055447043 @default.
- W2084823895 cites W2057831089 @default.
- W2084823895 cites W2060815067 @default.
- W2084823895 cites W2061843618 @default.
- W2084823895 cites W2066618129 @default.
- W2084823895 cites W2069137207 @default.
- W2084823895 cites W2073091304 @default.
- W2084823895 cites W2086692663 @default.
- W2084823895 cites W2091119618 @default.
- W2084823895 cites W2103031848 @default.
- W2084823895 cites W2106539380 @default.
- W2084823895 cites W2106644304 @default.
- W2084823895 cites W2113317598 @default.
- W2084823895 cites W2113989947 @default.
- W2084823895 cites W2114232003 @default.
- W2084823895 cites W2118725846 @default.
- W2084823895 cites W2119882682 @default.
- W2084823895 cites W2121948273 @default.
- W2084823895 cites W2122242241 @default.
- W2084823895 cites W2122588714 @default.
- W2084823895 cites W2123404136 @default.
- W2084823895 cites W2125344994 @default.
- W2084823895 cites W2125916336 @default.
- W2084823895 cites W2126322697 @default.
- W2084823895 cites W2128168840 @default.
- W2084823895 cites W2131202416 @default.
- W2084823895 cites W2132019469 @default.
- W2084823895 cites W2132831536 @default.
- W2084823895 cites W2133193835 @default.
- W2084823895 cites W2134112682 @default.
- W2084823895 cites W2137983259 @default.
- W2084823895 cites W2144728028 @default.
- W2084823895 cites W2145661830 @default.
- W2084823895 cites W2146744701 @default.
- W2084823895 cites W2147750283 @default.
- W2084823895 cites W2152350731 @default.
- W2084823895 cites W2154568166 @default.
- W2084823895 cites W2162420892 @default.
- W2084823895 cites W2170474645 @default.
- W2084823895 cites W2172702018 @default.
- W2084823895 cites W2322417031 @default.
- W2084823895 cites W23490311 @default.
- W2084823895 cites W4205713171 @default.
- W2084823895 cites W4211030739 @default.
- W2084823895 cites W4237277650 @default.
- W2084823895 cites W4376626789 @default.
- W2084823895 doi "https://doi.org/10.1016/j.mehy.2009.04.058" @default.
- W2084823895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19577852" @default.
- W2084823895 hasPublicationYear "2009" @default.
- W2084823895 type Work @default.
- W2084823895 sameAs 2084823895 @default.
- W2084823895 citedByCount "10" @default.
- W2084823895 countsByYear W20848238952013 @default.
- W2084823895 countsByYear W20848238952015 @default.
- W2084823895 countsByYear W20848238952016 @default.
- W2084823895 countsByYear W20848238952017 @default.
- W2084823895 countsByYear W20848238952019 @default.
- W2084823895 countsByYear W20848238952023 @default.
- W2084823895 crossrefType "journal-article" @default.
- W2084823895 hasAuthorship W2084823895A5035542322 @default.
- W2084823895 hasAuthorship W2084823895A5053802958 @default.