FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084824944> ?p ?o ?g. }

• W2084824944 endingPage "553" @default.
• W2084824944 startingPage "548" @default.
• W2084824944 abstract "Objective We hypothesized that, similar to idiopathic hip osteonecrosis, the T−786C mutation of the endothelial nitric oxide synthase (eNOS) gene affecting nitric oxide (NO) production was associated with neuralgia-inducing cavitational osteonecrosis of the jaws (NICO). Design In 22 NICO patients, not having taken bisphosphonates, mutations affecting NO production (eNOS T−786C, stromelysin 5A6A) were measured by polymerase chain reaction. Two healthy normal control subjects were matched per case by race and gender. Results Homozygosity for the mutant eNOS allele (TT) was present in 6 out of 22 patients (27%) with NICO compared with 0 out of 44 (0%) race and gender–matched control subjects; heterozygosity (TC) was present in 8 patients (36%) versus 15 control subjects (34%); and the wild-type normal genotype (CC) was present in 9 patients (36%) versus 29 controls (66%) (P = .0008). The mutant eNOS T−786C allele was more common in cases (20 out of 44 [45%]) than in control subjects (15 out of 88 [17%]) (P = .0005). The distribution of the stromelysin 5A6A genotype in cases did not differ from control subjects (P = .13). Conclusions The eNOS T−786C polymorphism affecting NO production is associated with NICO, may contribute to the pathogenesis of NICO, and may open therapeutic medical approaches to treatment of NICO through provision of L-arginine, the amino-acid precursor of NO. We hypothesized that, similar to idiopathic hip osteonecrosis, the T−786C mutation of the endothelial nitric oxide synthase (eNOS) gene affecting nitric oxide (NO) production was associated with neuralgia-inducing cavitational osteonecrosis of the jaws (NICO). In 22 NICO patients, not having taken bisphosphonates, mutations affecting NO production (eNOS T−786C, stromelysin 5A6A) were measured by polymerase chain reaction. Two healthy normal control subjects were matched per case by race and gender. Homozygosity for the mutant eNOS allele (TT) was present in 6 out of 22 patients (27%) with NICO compared with 0 out of 44 (0%) race and gender–matched control subjects; heterozygosity (TC) was present in 8 patients (36%) versus 15 control subjects (34%); and the wild-type normal genotype (CC) was present in 9 patients (36%) versus 29 controls (66%) (P = .0008). The mutant eNOS T−786C allele was more common in cases (20 out of 44 [45%]) than in control subjects (15 out of 88 [17%]) (P = .0005). The distribution of the stromelysin 5A6A genotype in cases did not differ from control subjects (P = .13). The eNOS T−786C polymorphism affecting NO production is associated with NICO, may contribute to the pathogenesis of NICO, and may open therapeutic medical approaches to treatment of NICO through provision of L-arginine, the amino-acid precursor of NO." @default.
• W2084824944 created "2016-06-24" @default.
• W2084824944 creator A5013736647 @default.
• W2084824944 creator A5014202578 @default.
• W2084824944 creator A5031202932 @default.
• W2084824944 creator A5079058910 @default.
• W2084824944 creator A5080631865 @default.
• W2084824944 date "2010-04-01" @default.
• W2084824944 modified "2023-09-26" @default.
• W2084824944 title "T−786C polymorphism of the endothelial nitric oxide synthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws" @default.
• W2084824944 cites W12601458 @default.
• W2084824944 cites W1511769072 @default.
• W2084824944 cites W1597805897 @default.
• W2084824944 cites W1923431048 @default.
• W2084824944 cites W1965158415 @default.
• W2084824944 cites W1972877115 @default.
• W2084824944 cites W1976492249 @default.
• W2084824944 cites W1984964064 @default.
• W2084824944 cites W1987710787 @default.
• W2084824944 cites W1988988785 @default.
• W2084824944 cites W1992459749 @default.
• W2084824944 cites W1996159509 @default.
• W2084824944 cites W2006230254 @default.
• W2084824944 cites W2007204443 @default.
• W2084824944 cites W2009422365 @default.
• W2084824944 cites W2021541380 @default.
• W2084824944 cites W2025085419 @default.
• W2084824944 cites W2025417526 @default.
• W2084824944 cites W2025560251 @default.
• W2084824944 cites W2028836288 @default.
• W2084824944 cites W2037981313 @default.
• W2084824944 cites W2047788536 @default.
• W2084824944 cites W2050057977 @default.
• W2084824944 cites W2063698008 @default.
• W2084824944 cites W2073429235 @default.
• W2084824944 cites W2091557419 @default.
• W2084824944 cites W2102221122 @default.
• W2084824944 cites W2116706953 @default.
• W2084824944 cites W2118958365 @default.
• W2084824944 cites W2123983302 @default.
• W2084824944 cites W2128033981 @default.
• W2084824944 cites W2132176542 @default.
• W2084824944 cites W2147534219 @default.
• W2084824944 cites W2151712386 @default.
• W2084824944 cites W2154694989 @default.
• W2084824944 cites W2164653101 @default.
• W2084824944 doi "https://doi.org/10.1016/j.tripleo.2009.11.011" @default.
• W2084824944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20185342" @default.
• W2084824944 hasPublicationYear "2010" @default.
• W2084824944 type Work @default.
• W2084824944 sameAs 2084824944 @default.
• W2084824944 citedByCount "14" @default.
• W2084824944 countsByYear W20848249442012 @default.
• W2084824944 countsByYear W20848249442013 @default.
• W2084824944 countsByYear W20848249442014 @default.
• W2084824944 countsByYear W20848249442015 @default.
• W2084824944 countsByYear W20848249442016 @default.
• W2084824944 countsByYear W20848249442017 @default.
• W2084824944 countsByYear W20848249442019 @default.
• W2084824944 countsByYear W20848249442021 @default.
• W2084824944 crossrefType "journal-article" @default.
• W2084824944 hasAuthorship W2084824944A5013736647 @default.
• W2084824944 hasAuthorship W2084824944A5014202578 @default.
• W2084824944 hasAuthorship W2084824944A5031202932 @default.
• W2084824944 hasAuthorship W2084824944A5079058910 @default.
• W2084824944 hasAuthorship W2084824944A5080631865 @default.
• W2084824944 hasBestOaLocation W20848249442 @default.
• W2084824944 hasConcept C104317684 @default.
• W2084824944 hasConcept C126322002 @default.
• W2084824944 hasConcept C134018914 @default.
• W2084824944 hasConcept C135763542 @default.
• W2084824944 hasConcept C180754005 @default.
• W2084824944 hasConcept C2777622882 @default.
• W2084824944 hasConcept C2778326061 @default.
• W2084824944 hasConcept C2780942790 @default.
• W2084824944 hasConcept C2908688039 @default.
• W2084824944 hasConcept C519581460 @default.
• W2084824944 hasConcept C54355233 @default.
• W2084824944 hasConcept C71924100 @default.
• W2084824944 hasConcept C86803240 @default.
• W2084824944 hasConcept C90924648 @default.
• W2084824944 hasConceptScore W2084824944C104317684 @default.
• W2084824944 hasConceptScore W2084824944C126322002 @default.
• W2084824944 hasConceptScore W2084824944C134018914 @default.
• W2084824944 hasConceptScore W2084824944C135763542 @default.
• W2084824944 hasConceptScore W2084824944C180754005 @default.
• W2084824944 hasConceptScore W2084824944C2777622882 @default.
• W2084824944 hasConceptScore W2084824944C2778326061 @default.
• W2084824944 hasConceptScore W2084824944C2780942790 @default.
• W2084824944 hasConceptScore W2084824944C2908688039 @default.
• W2084824944 hasConceptScore W2084824944C519581460 @default.
• W2084824944 hasConceptScore W2084824944C54355233 @default.
• W2084824944 hasConceptScore W2084824944C71924100 @default.
• W2084824944 hasConceptScore W2084824944C86803240 @default.
• W2084824944 hasConceptScore W2084824944C90924648 @default.
• W2084824944 hasIssue "4" @default.
• W2084824944 hasLocation W20848249441 @default.
• W2084824944 hasLocation W20848249442 @default.

• next