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• W2084851681 abstract "The facultative intracellular pathogen Aeromonas salmonicida survives and replicates in macrophages, a virulence trait presumed to be associated with its ability to resist reactive radicals. The mechanisms used by A. salmonicida to resist reactive radicals in vitro were shown to have both structural and physiological determinants. The sensitivity of A. salmonicida to exogenous H 2 O 2 , superoxide, and nitrogen radicals, as well as endogenous oxygen radicals, differed depending on growth conditions, cell surface structure, and preexposure to sublethal doses of radicals. Whereas sensitivities to exogenous oxygen radicals did not correlate with basal levels of catalase or Fe-superoxide dismutase, under similar culture conditions S-layer positive cells were more resistant to oxygen radicals than S-layer mutants. S-layer mutants recovered resistance when physically reconstituted with S-layer sheets. Hemin-coated S-layers, while protective against nitrogen radicals, sensitized A. salmonicida to H 2 O 2 . Sublethal concentrations of H 2 O 2 or superoxide induced a highly protective response characterized by de novo synthesis of both catalase and Mn-superoxide dismutase. It is proposed that for A. salmonicida the constitutive S-layer provides a first line of defense and the inducible catalase and Mn-superoxide dismutase provide a powerful second line of defense against macrophage-mediated killing via reactive oxygen species.Key words: Aeromonas salmonicida, oxygen radicals, nitrogen radicals, oxidative stress, S-layers." @default.
• W2084851681 created "2016-06-24" @default.
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• W2084851681 date "1997-11-01" @default.
• W2084851681 modified "2023-10-15" @default.
• W2084851681 title "Structural and physiological determinants of resistance of<i>Aeromonas salmonicida</i>to reactive radicals" @default.
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• W2084851681 doi "https://doi.org/10.1139/m97-149" @default.
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