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- W2084865245 abstract "Addition of dopamine to the solution bathing the basolateral surface of Necturus gallbladder (NGB) caused cell membrane depolarization, a fall in the apparent electrical resistance of the apical membrane, a transient depolarizing response to a reduction in apical solution [Cl-], and a decrease in transepithelial fluid absorption. These results are consistent with a dopamine-mediated increase in apical membrane Cl– conductance (Gcιa). The half-maximal concentration for the effect of dopamine was approximately 1 µM. Most experiments were carried out with 10 µM. The effects of dopamine were abolished by a D1 receptor antagonist, and unchanged by a D2 receptor antagonist. Dopamine produced a ∼10-fold increase in cAMP tissue content. Because in NGB epithelium acetylcholine (ACh) inhibits adenylate cyclase via an inhibitory G protein [Altenberg et al.: Am. J. Physiol., in press], we tested the effect of ACh on the response to dopamine. ACh (10 µM, basolateral solution) abolished the effects of dopamine on fluid absorption, Gcιa and cAMP levels. We conclude that in NGB epithelium dopamine activates Gcιa by stimulation of D1-like receptors. This causes stimulation of adenylate cyclase and elevation of intracellular cAMP. The effects of dopamine are abolished by acetylcholine, which inhibits adenylate cyclase." @default.
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- W2084865245 date "1995-01-01" @default.
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- W2084865245 title "Dopamine Activates Apical Membrane Cl<sup>–</sup> Conductance and Inhibits Fluid Absorption in Amphibian Gallbladder by Elevating Intracellular cAMP" @default.
- W2084865245 doi "https://doi.org/10.1159/000154746" @default.
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