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• W2084877215 abstract "Au naturel! (+)-Usnic acid (green) is a weak antimalarial agent, however, in conjugation with known antimalarial scaffolds and drugs, such as dihydroartemisinin (blue), potent activity against the blood-stage parasite can be seen both in vitro and in vivo. The compound shown exhibits an IC(50) value of 1.4 nM against Plasmodium falciparum in vitro and proved nearly as efficacious as artesunate in a mouse model of infection." @default.
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• W2084877215 date "2013-01-10" @default.
• W2084877215 modified "2023-09-26" @default.
• W2084877215 title "Synthesis of a Potent Antimalarial Agent through Natural Products Conjugation" @default.
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• W2084877215 doi "https://doi.org/10.1002/cmdc.201200503" @default.
• W2084877215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3836189" @default.
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