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• W2084890228 abstract "p38 has been implicated to play a critical role in regulating apoptosis in PC12 and cerebellar granule cells, and is inactivated in cultured fetal neurons in response to insulin. Though p38 is activated in microglia after ischemia, the physiological functions of p38 in the brain are not well understood. As a first step to elucidate the physiological functions of p38 in the central nervous system, we raised a polyclonal antibody against p38 and performed immunohistochemical examination to demonstrate the localization of p38 in mouse brain. Strong p38 immunoreactivity was apparent in fiber bundles including the olfactory tract, anterior commissure, corpus callosum, cingulum, internal capsule, stria terminalis, fimbria and alveus hippocampi, fornix, stria medullaris, optic chiasm and optic tract. Although similar regions were stained with both anti-p38 and anti-neurofilament antibodies, intense p38 immunoreactivity was often observed in myelin sheath-like structures but not in axons. This is the first demonstration of the localization of p38 in the central nervous system and provides an anatomical basis for understanding physiological roles of p38." @default.
• W2084890228 created "2016-06-24" @default.
• W2084890228 creator A5012015684 @default.
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• W2084890228 date "2000-12-01" @default.
• W2084890228 modified "2023-10-17" @default.
• W2084890228 title "Immunolocalization of p38 MAP kinase in mouse brain" @default.
• W2084890228 cites W1915946375 @default.
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• W2084890228 doi "https://doi.org/10.1016/s0006-8993(00)03063-8" @default.
• W2084890228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11134625" @default.
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