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• W2084902016 abstract "In vitro fertilisation with embryo transfer (IVFET) is associated with an increased risk of venous thrombosis. In order to determine to which extent the hormonal preparation required for IVFET could be involved in this complication, we have measured major plasma fibrinolytic components in 13 women before and during the ovarian stimulation. After pituitary desensitization with buserelin, plasma levels of fibrin degradation products (FbDP) and fibrinogen were significantly decreased. Tissue-type plasminogen activator antigen (t-PA), plasminogen activator inhibitor 1 antigen (PAI-1), FbDP and fibrinopeptide A remained unchanged. After a subsequent stimulation by human menopausal gonadotropins, FbDP plasma levels remained low, while fibrinogen returned to normal levels. t-PA antigen and PAI-1 antigen plasma levels decreased and were correlated with increased serum estradiol levels. Therefore, estradiol could be involved in the regulation of the fibrinolytic balance to some extent; during IVFET hormonal preparation, a decreased plasma fibrinolytic capacity can be questioned, thus favouring the appearance of a thrombotic event." @default.
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• W2084902016 date "1993-09-01" @default.
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• W2084902016 title "Decreased plasma fibrin degradation products during hormonal stimulation for in vitro fertilisation" @default.
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• W2084902016 doi "https://doi.org/10.1016/0268-9499(93)90151-k" @default.
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