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• W2084905080 abstract "Background: Previous studies demonstrate that macrophages synthesis and release catecholamines, which regulate the immune responses in an autocrine manner. These responses are mediated in part by β-adrenoceptors expressed on macrophages. Some β-adrenoceptor antagonists are commonly used in clinical conditions. Here we investigated whether the chronic administration of β-adrenoceptor antagonists upregulate adrenergic system of alveolar macrophage and the potential mechanims. Methods: Propranolol (30 mg/kg·d) or atenolol (5 mg/kg·d) was administered by gavage to rats for 4 weeks. Then alveolar macrophages were isolated and the expression of β₁ or β₂-adrenoceptor was detected by flow cytometric analysis. Dopamine β-hydroxylase expression was assessed by Western blot assay and the concentrations of noradrenaline, IL-6, and TNF-α in cell supernatants were measured using ELISA after 2 h or 24 h exposure of alveolar macrophages to 100 ng/ml lipopolysaccharide (LPS). Results: Propranolol increased the mean fluorescence intensity (MFI) of β₁, β₂-adrenoceptor and the frequency of β₁-,β₂- adrenoceptor positive macrophages. However, only the MFI of β₁-adrenoceptor and the frequency of β₁-adrenoceptor positive macrophages were increased by atenolol. Furthermore, both propranolol and atenolol promoted LPS-mediated dopamine β-hydroxylase protein expression and increased noradrenaline production in rat alveolar macrophages. This was accompanied by increased LPS-mediated IL-6 and TNF-α production in cell supernatants of alveolar macrophages. Conclusion: These findings demonstrate that propranolol or atenolol upregulates alveolar macrophage adrenergic system, and the response may be β₁-adrenergic receptor subtype dependent." @default.
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• W2084905080 date "2011-01-01" @default.
• W2084905080 modified "2023-09-27" @default.
• W2084905080 title "Chronic β-adrenoceptor Antagonists Upregulate the Rat Alveolar Macrophage Adrenergic System Through the β₁-Subtype" @default.
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• W2084905080 doi "https://doi.org/10.1159/000331747" @default.
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