FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084910248> ?p ?o ?g. }

• W2084910248 endingPage "8642" @default.
• W2084910248 startingPage "8636" @default.
• W2084910248 abstract "Hyperglycemia and advanced glycation end products (AGEs) are associated with an elevated risk of developing several cancers in diabetic patients. However, the detailed mechanisms remain to be elucidated. The mechanism of AGE-bovine serum albumin (BSA) on gap junction intercellular communication in human hepatoma cell line, SKHep 1, was investigated. Both Cx32 and Cx43 are major gap junction forming proteins in the liver, the loss of which has been shown to facilitate tumorigenesis. Although the MTT assay results showed that AGE-BSA significantly increased cell growth by 31%, AGE-BSA down-regulated Cx32 and Cx43 expression in a dose- and time-dependent manner. The present study also demonstrated that ERK1/2 and JNK/SAPK were significantly activated by AGE-BSA and that Src, ERK1/2, and JNK/SAPK inhibitors significantly reversed the reduction of Cx32 and Cx43 proteins by AGE-BSA. Taken together, these results strongly support the hypothesis that Src-dependent ERK1/2 and JNK/SAPK/AP1 signaling pathways play a key role in AGE-BSA-mediated down-regulation of Cx32 and Cx43 protein expression in SKHep 1 cells." @default.
• W2084910248 created "2016-06-24" @default.
• W2084910248 creator A5000983085 @default.
• W2084910248 creator A5004514413 @default.
• W2084910248 creator A5037144696 @default.
• W2084910248 creator A5044363517 @default.
• W2084910248 creator A5057746868 @default.
• W2084910248 date "2010-07-14" @default.
• W2084910248 modified "2023-09-25" @default.
• W2084910248 title "Advanced Glycation End Products Down-regulate Gap Junctions in Human Hepatoma SKHep 1 Cells via the Activation of Src-Dependent ERK1/2 and JNK/SAPK/AP1 Signaling Pathways" @default.
• W2084910248 cites W129162332 @default.
• W2084910248 cites W1759816341 @default.
• W2084910248 cites W1964979152 @default.
• W2084910248 cites W1971915141 @default.
• W2084910248 cites W2005653939 @default.
• W2084910248 cites W2005877077 @default.
• W2084910248 cites W2012323130 @default.
• W2084910248 cites W2014037575 @default.
• W2084910248 cites W2030754590 @default.
• W2084910248 cites W2061438193 @default.
• W2084910248 cites W2062887543 @default.
• W2084910248 cites W2064532629 @default.
• W2084910248 cites W2084459692 @default.
• W2084910248 cites W2086439895 @default.
• W2084910248 cites W2096184839 @default.
• W2084910248 cites W2101884192 @default.
• W2084910248 cites W2105183213 @default.
• W2084910248 cites W2111152746 @default.
• W2084910248 cites W2133128079 @default.
• W2084910248 cites W2152820752 @default.
• W2084910248 cites W2157441872 @default.
• W2084910248 cites W2158968180 @default.
• W2084910248 cites W2161016685 @default.
• W2084910248 cites W2316598086 @default.
• W2084910248 cites W2339404567 @default.
• W2084910248 cites W4247904703 @default.
• W2084910248 cites W4254268911 @default.
• W2084910248 doi "https://doi.org/10.1021/jf904240c" @default.
• W2084910248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20681653" @default.
• W2084910248 hasPublicationYear "2010" @default.
• W2084910248 type Work @default.
• W2084910248 sameAs 2084910248 @default.
• W2084910248 citedByCount "7" @default.
• W2084910248 countsByYear W20849102482013 @default.
• W2084910248 countsByYear W20849102482015 @default.
• W2084910248 countsByYear W20849102482018 @default.
• W2084910248 countsByYear W20849102482019 @default.
• W2084910248 countsByYear W20849102482021 @default.
• W2084910248 crossrefType "journal-article" @default.
• W2084910248 hasAuthorship W2084910248A5000983085 @default.
• W2084910248 hasAuthorship W2084910248A5004514413 @default.
• W2084910248 hasAuthorship W2084910248A5037144696 @default.
• W2084910248 hasAuthorship W2084910248A5044363517 @default.
• W2084910248 hasAuthorship W2084910248A5057746868 @default.
• W2084910248 hasConcept C102280478 @default.
• W2084910248 hasConcept C104317684 @default.
• W2084910248 hasConcept C108636557 @default.
• W2084910248 hasConcept C147990577 @default.
• W2084910248 hasConcept C150194340 @default.
• W2084910248 hasConcept C158157758 @default.
• W2084910248 hasConcept C169760540 @default.
• W2084910248 hasConcept C170493617 @default.
• W2084910248 hasConcept C185592680 @default.
• W2084910248 hasConcept C2778857457 @default.
• W2084910248 hasConcept C502942594 @default.
• W2084910248 hasConcept C55493867 @default.
• W2084910248 hasConcept C555283112 @default.
• W2084910248 hasConcept C62112901 @default.
• W2084910248 hasConcept C62478195 @default.
• W2084910248 hasConcept C79879829 @default.
• W2084910248 hasConcept C86803240 @default.
• W2084910248 hasConcept C86807702 @default.
• W2084910248 hasConcept C95444343 @default.
• W2084910248 hasConceptScore W2084910248C102280478 @default.
• W2084910248 hasConceptScore W2084910248C104317684 @default.
• W2084910248 hasConceptScore W2084910248C108636557 @default.
• W2084910248 hasConceptScore W2084910248C147990577 @default.
• W2084910248 hasConceptScore W2084910248C150194340 @default.
• W2084910248 hasConceptScore W2084910248C158157758 @default.
• W2084910248 hasConceptScore W2084910248C169760540 @default.
• W2084910248 hasConceptScore W2084910248C170493617 @default.
• W2084910248 hasConceptScore W2084910248C185592680 @default.
• W2084910248 hasConceptScore W2084910248C2778857457 @default.
• W2084910248 hasConceptScore W2084910248C502942594 @default.
• W2084910248 hasConceptScore W2084910248C55493867 @default.
• W2084910248 hasConceptScore W2084910248C555283112 @default.
• W2084910248 hasConceptScore W2084910248C62112901 @default.
• W2084910248 hasConceptScore W2084910248C62478195 @default.
• W2084910248 hasConceptScore W2084910248C79879829 @default.
• W2084910248 hasConceptScore W2084910248C86803240 @default.
• W2084910248 hasConceptScore W2084910248C86807702 @default.
• W2084910248 hasConceptScore W2084910248C95444343 @default.
• W2084910248 hasIssue "15" @default.
• W2084910248 hasLocation W20849102481 @default.
• W2084910248 hasLocation W20849102482 @default.
• W2084910248 hasOpenAccess W2084910248 @default.
• W2084910248 hasPrimaryLocation W20849102481 @default.
• W2084910248 hasRelatedWork W1963843984 @default.

• next