FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084920222> ?p ?o ?g. }

• W2084920222 endingPage "338" @default.
• W2084920222 startingPage "333" @default.
• W2084920222 abstract "Freshly excised human head and neck cancers (219 primary cancers; 64 metastatic lymph node cancers) were analyzed for the immune inhibitory mediators released from the cancer tissues and the immune infiltrate within the tumor. Significant levels of the immune inhibitory mediators transforming growth factor-β (TGF-β), prostaglandin E2 (PGE2) and interleukin-10 (IL-10) were released from these cancers. Also released was granulocyte-macrophage colony-stimulating factor (GM-CSF), whose secretion was associated with an intratumoral presence of CD34+ cells. We have previously shown that CD34+ cells within human head and neck cancers are immune inhibitory granulocyte-macrophage progenitor cells. The presence of TGF-β, PGE2 and IL-10 was associated with a reduced content of CD8+ T-cells within the cancers. The CD4+ cell content appeared to be less affected by these immune inhibitory mediators. Instead, parameters indicative of CD4+ cell function (p55 IL-2 receptor expression, release of IL-2 and IFN-γ) were diminished in cancers that released higher levels of TGF-β, IL-10 and GM-CSF and had a higher CD34+ cell content. Furthermore, metastatic cancers released higher levels of the soluble immune inhibitory mediators and lower levels of IFN-γ and IL-2 than did primary cancers, although CD34+ cells were similarly present in both primary and metastatic cancers. Our results show that human head and neck cancers have a multiplicity of non-mutually exclusive mechanisms of immune suppression that are most prominently associated with reduced CD8+ cell influx and reduced influx and altered function of intratumoral CD4+ cells. © 1996 Wiley-Liss, Inc." @default.
• W2084920222 created "2016-06-24" @default.
• W2084920222 creator A5000681392 @default.
• W2084920222 creator A5008238353 @default.
• W2084920222 creator A5046145281 @default.
• W2084920222 creator A5052058621 @default.
• W2084920222 creator A5090893010 @default.
• W2084920222 creator A5091834823 @default.
• W2084920222 date "1996-07-29" @default.
• W2084920222 modified "2023-10-10" @default.
• W2084920222 title "Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer" @default.
• W2084920222 cites W1540455628 @default.
• W2084920222 cites W1546319410 @default.
• W2084920222 cites W1555981383 @default.
• W2084920222 cites W1575706012 @default.
• W2084920222 cites W1576287037 @default.
• W2084920222 cites W1603072371 @default.
• W2084920222 cites W1651198898 @default.
• W2084920222 cites W1921114390 @default.
• W2084920222 cites W1972942797 @default.
• W2084920222 cites W1973915978 @default.
• W2084920222 cites W1975078287 @default.
• W2084920222 cites W1990032533 @default.
• W2084920222 cites W1991148746 @default.
• W2084920222 cites W2000446337 @default.
• W2084920222 cites W2006598591 @default.
• W2084920222 cites W2006674162 @default.
• W2084920222 cites W2016527985 @default.
• W2084920222 cites W2020172203 @default.
• W2084920222 cites W2021888738 @default.
• W2084920222 cites W2036129060 @default.
• W2084920222 cites W2048409168 @default.
• W2084920222 cites W2056419915 @default.
• W2084920222 cites W2064517738 @default.
• W2084920222 cites W2070419032 @default.
• W2084920222 cites W2075942059 @default.
• W2084920222 cites W2080287537 @default.
• W2084920222 cites W2088953386 @default.
• W2084920222 cites W2124264905 @default.
• W2084920222 cites W2130454671 @default.
• W2084920222 cites W2131443622 @default.
• W2084920222 cites W2133819305 @default.
• W2084920222 cites W2147617276 @default.
• W2084920222 cites W2148631199 @default.
• W2084920222 cites W2164044495 @default.
• W2084920222 cites W2168995011 @default.
• W2084920222 cites W2331088526 @default.
• W2084920222 cites W2399007860 @default.
• W2084920222 cites W2419434076 @default.
• W2084920222 doi "https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<333::aid-ijc5>3.0.co;2-s" @default.
• W2084920222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8707405" @default.
• W2084920222 hasPublicationYear "1996" @default.
• W2084920222 type Work @default.
• W2084920222 sameAs 2084920222 @default.
• W2084920222 citedByCount "173" @default.
• W2084920222 countsByYear W20849202222012 @default.
• W2084920222 countsByYear W20849202222013 @default.
• W2084920222 countsByYear W20849202222014 @default.
• W2084920222 countsByYear W20849202222015 @default.
• W2084920222 countsByYear W20849202222016 @default.
• W2084920222 countsByYear W20849202222017 @default.
• W2084920222 countsByYear W20849202222018 @default.
• W2084920222 countsByYear W20849202222019 @default.
• W2084920222 countsByYear W20849202222020 @default.
• W2084920222 countsByYear W20849202222021 @default.
• W2084920222 countsByYear W20849202222022 @default.
• W2084920222 countsByYear W20849202222023 @default.
• W2084920222 crossrefType "journal-article" @default.
• W2084920222 hasAuthorship W2084920222A5000681392 @default.
• W2084920222 hasAuthorship W2084920222A5008238353 @default.
• W2084920222 hasAuthorship W2084920222A5046145281 @default.
• W2084920222 hasAuthorship W2084920222A5052058621 @default.
• W2084920222 hasAuthorship W2084920222A5090893010 @default.
• W2084920222 hasAuthorship W2084920222A5091834823 @default.
• W2084920222 hasConcept C121608353 @default.
• W2084920222 hasConcept C126322002 @default.
• W2084920222 hasConcept C167672396 @default.
• W2084920222 hasConcept C203014093 @default.
• W2084920222 hasConcept C2778690821 @default.
• W2084920222 hasConcept C2780849966 @default.
• W2084920222 hasConcept C502942594 @default.
• W2084920222 hasConcept C71924100 @default.
• W2084920222 hasConcept C86803240 @default.
• W2084920222 hasConcept C8891405 @default.
• W2084920222 hasConceptScore W2084920222C121608353 @default.
• W2084920222 hasConceptScore W2084920222C126322002 @default.
• W2084920222 hasConceptScore W2084920222C167672396 @default.
• W2084920222 hasConceptScore W2084920222C203014093 @default.
• W2084920222 hasConceptScore W2084920222C2778690821 @default.
• W2084920222 hasConceptScore W2084920222C2780849966 @default.
• W2084920222 hasConceptScore W2084920222C502942594 @default.
• W2084920222 hasConceptScore W2084920222C71924100 @default.
• W2084920222 hasConceptScore W2084920222C86803240 @default.
• W2084920222 hasConceptScore W2084920222C8891405 @default.
• W2084920222 hasIssue "3" @default.
• W2084920222 hasLocation W20849202221 @default.
• W2084920222 hasLocation W20849202222 @default.
• W2084920222 hasOpenAccess W2084920222 @default.

• next