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- W2084920598 abstract "Controlled clinical trials have shown that optimal glycemic control can prevent the microvascular complications of type 2 diabetes mellitus; considerable epidemiological data suggest that this may also be true for macrovascular complications. However, this is frequently not achieved. Consequently, research efforts have been undertaken to better understand the pathophysiology of this disorder. It is now well recognized that 2 factors are involved: impaired beta-cell function and insulin resistance. Prospective studies of high-risk populations have shown insulin-resistance and/ or insulin-secretory defects before the onset of impaired glucose tolerance. Thus, there has been a long-standing debate whether an alteration in insulin sensitivity or in insulin secretion is the primary genetic factor. Most of the available evidence favors the view that type 2 diabetes is a heterogeneous disorder in which the major genetic factor is impaired beta-cell function and insulin resistance is the major acquired factor. Superimposition of insulin resistance on a beta cell that cannot appropriately compensate leads to deterioration in glucose tolerance. Therefore, clinicians managing type 2 diabetes must reduce insulin resistance and augment and/or replace beta-cell function." @default.
- W2084920598 created "2016-06-24" @default.
- W2084920598 creator A5016468114 @default.
- W2084920598 date "2003-04-01" @default.
- W2084920598 modified "2023-10-10" @default.
- W2084920598 title "Contributions of Insulin-Resistance and Insulin-Secretory Defects to the Pathogenesis of Type 2 Diabetes Mellitus" @default.
- W2084920598 cites W1524321743 @default.
- W2084920598 cites W1539694845 @default.
- W2084920598 cites W1575823472 @default.
- W2084920598 cites W1587875569 @default.
- W2084920598 cites W1675830194 @default.
- W2084920598 cites W1966238409 @default.
- W2084920598 cites W1969023742 @default.
- W2084920598 cites W1970582410 @default.
- W2084920598 cites W1975359117 @default.
- W2084920598 cites W1975588287 @default.
- W2084920598 cites W1976787772 @default.
- W2084920598 cites W1977274289 @default.
- W2084920598 cites W1978062520 @default.
- W2084920598 cites W1984297603 @default.
- W2084920598 cites W1997582814 @default.
- W2084920598 cites W1998420980 @default.
- W2084920598 cites W2004750236 @default.
- W2084920598 cites W2007543302 @default.
- W2084920598 cites W2009179022 @default.
- W2084920598 cites W2011133973 @default.
- W2084920598 cites W2011932428 @default.
- W2084920598 cites W2012655679 @default.
- W2084920598 cites W2015546180 @default.
- W2084920598 cites W2021838776 @default.
- W2084920598 cites W2026528846 @default.
- W2084920598 cites W2030153054 @default.
- W2084920598 cites W2031032207 @default.
- W2084920598 cites W2035481611 @default.
- W2084920598 cites W2037480044 @default.
- W2084920598 cites W2041176514 @default.
- W2084920598 cites W2044007450 @default.
- W2084920598 cites W2046766433 @default.
- W2084920598 cites W2047590400 @default.
- W2084920598 cites W2050082711 @default.
- W2084920598 cites W2050743053 @default.
- W2084920598 cites W2051313176 @default.
- W2084920598 cites W2055645626 @default.
- W2084920598 cites W2056319298 @default.
- W2084920598 cites W2062078854 @default.
- W2084920598 cites W2067096633 @default.
- W2084920598 cites W2075734883 @default.
- W2084920598 cites W2075952932 @default.
- W2084920598 cites W2078089300 @default.
- W2084920598 cites W2078807483 @default.
- W2084920598 cites W2079379175 @default.
- W2084920598 cites W2084006515 @default.
- W2084920598 cites W2085392333 @default.
- W2084920598 cites W2086546194 @default.
- W2084920598 cites W2090582239 @default.
- W2084920598 cites W2090824142 @default.
- W2084920598 cites W2094129019 @default.
- W2084920598 cites W2101766292 @default.
- W2084920598 cites W2104310970 @default.
- W2084920598 cites W2105026884 @default.
- W2084920598 cites W2108931588 @default.
- W2084920598 cites W2109510102 @default.
- W2084920598 cites W2109955513 @default.
- W2084920598 cites W2110121134 @default.
- W2084920598 cites W2110305332 @default.
- W2084920598 cites W2123946565 @default.
- W2084920598 cites W2124912126 @default.
- W2084920598 cites W2127934772 @default.
- W2084920598 cites W2130935482 @default.
- W2084920598 cites W2131287528 @default.
- W2084920598 cites W2133082625 @default.
- W2084920598 cites W2140937253 @default.
- W2084920598 cites W2146536851 @default.
- W2084920598 cites W2152591650 @default.
- W2084920598 cites W2155904812 @default.
- W2084920598 cites W2155951466 @default.
- W2084920598 cites W2156353972 @default.
- W2084920598 cites W2158822657 @default.
- W2084920598 cites W2161144814 @default.
- W2084920598 cites W2161381121 @default.
- W2084920598 cites W2164126844 @default.
- W2084920598 cites W2169558934 @default.
- W2084920598 cites W2188846692 @default.
- W2084920598 cites W2327628147 @default.
- W2084920598 cites W2330273698 @default.
- W2084920598 cites W2330505590 @default.
- W2084920598 cites W2332951586 @default.
- W2084920598 cites W2334309509 @default.
- W2084920598 cites W2337454357 @default.
- W2084920598 cites W2769264260 @default.
- W2084920598 cites W4210952457 @default.
- W2084920598 cites W4210970044 @default.
- W2084920598 cites W4235391466 @default.
- W2084920598 cites W4235717978 @default.
- W2084920598 cites W4236552491 @default.
- W2084920598 cites W4236781677 @default.
- W2084920598 cites W4238251256 @default.
- W2084920598 cites W4239191207 @default.