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- W2084926712 abstract "Increased morbidity and mortality following transplantation surgery due to the primary nonfunction and dysfunction of the liver poses a great challenge and has increased the crescendo of research work in this field. In this study, we have tried to address the issue concerning the changes in Ca2+homeostasis and hepatic microcirculation in 90 min of ischemia followed by reperfusion of the liver after FK506 pretreatment. Twenty dogs divided into two groups; group I (0.15 mg/kg/day FK506 for 3 days, im) and group II (control) were used for the measurement of mitochondrial (mit) and total cellular Ca2+by atomic absorption spectrophotometer and hepatic microcirculation with laser Doppler flowmeter. Serum AST leakage was significantly (P< 0.05) suppressed in group I at 6 hr after reperfusion. The percentage gain in mit Ca2+in group I was significantly (P< 0.05) inhibited compared to that in group II at 15 min after reperfusion and also when compared with the preischemic value it was significantly (P< 0.05) elevated at 30 min after reperfusion in group II only. FK pretreatment significantly (P< 0.05) inhibited the overload in total cellular Ca2+at 15 and 30 min after reperfusion. Moreover, hepatic microcirculation was significantly (P< 0.001) better in group I between 2 and 6 hr after reperfusion. In conclusion, the ameliorating property of FK in ischemia–reperfusion may be explained by prevention of the cellular Ca2+overload during the perireperfusion period." @default.
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- W2084926712 date "1996-01-01" @default.
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- W2084926712 title "FK506 Maintains Cellular Calcium Homeostasis in Ischemia–Reperfusion Injury of the Canine Liver" @default.
- W2084926712 doi "https://doi.org/10.1006/jsre.1996.0023" @default.
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