Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084927888> ?p ?o ?g. }
- W2084927888 endingPage "1365" @default.
- W2084927888 startingPage "1361" @default.
- W2084927888 abstract "Infection of medical implanted material is associated with considerable morbidity and costs. In the following work, we investigated the effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on biofilms formed by Staphylococcus epidermidis isolates causative for implant infection and catheter-associated bacteremia. Biofilms were studied using the static microtiter plate model and incubated with the antibiotics increasing the concentration from 1x to 128 x the minimal inhibitory concentration (MIC) of the respective isolate tested. To quantify the reduction of the biomass, the optical density ratio (ODr) of stained biofilms and the number of growing bacteria were determined. Incubation of the staphylococcal biofilms with the antibiotics decreased the biofilm ODr (at baseline = 1) for ceftriaxone (0.83 +/- 0.48) but minimally only for fosfomycin (0.96 +/- 0.64), daptomycin (1.05 +/- 0.59), tigecycline (1.18 +/- 0.66), and vancomycin (0.98 +/- 0.44) at exceedingly high concentrations of 128 x MIC. The significant reduction of the bacterial growth was not achieved for all antibiotics, not even at the highest concentrations tested. Using higher doses of the antibiotics may be of some value in the treatment of biofilm-associated infections, although effects are seen only at clinically unachievable doses. However, to eradicate the staphylococcal biofilm, additional measures like debridement and/or removal of the implant are needed." @default.
- W2084927888 created "2016-06-24" @default.
- W2084927888 creator A5003540685 @default.
- W2084927888 creator A5023471727 @default.
- W2084927888 creator A5055337379 @default.
- W2084927888 creator A5076990895 @default.
- W2084927888 creator A5081542680 @default.
- W2084927888 date "2009-04-24" @default.
- W2084927888 modified "2023-10-01" @default.
- W2084927888 title "Effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on<i>Staphylococcus epidermidis</i>biofilms" @default.
- W2084927888 cites W127304394 @default.
- W2084927888 cites W1563383420 @default.
- W2084927888 cites W1829418230 @default.
- W2084927888 cites W18650605 @default.
- W2084927888 cites W1929451968 @default.
- W2084927888 cites W1936526555 @default.
- W2084927888 cites W1958246973 @default.
- W2084927888 cites W1990315719 @default.
- W2084927888 cites W1990636299 @default.
- W2084927888 cites W2075359954 @default.
- W2084927888 cites W2084873537 @default.
- W2084927888 cites W2091251557 @default.
- W2084927888 cites W2106617775 @default.
- W2084927888 cites W2143661366 @default.
- W2084927888 cites W2150457138 @default.
- W2084927888 cites W2153825315 @default.
- W2084927888 doi "https://doi.org/10.1002/jor.20902" @default.
- W2084927888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19396814" @default.
- W2084927888 hasPublicationYear "2009" @default.
- W2084927888 type Work @default.
- W2084927888 sameAs 2084927888 @default.
- W2084927888 citedByCount "42" @default.
- W2084927888 countsByYear W20849278882012 @default.
- W2084927888 countsByYear W20849278882013 @default.
- W2084927888 countsByYear W20849278882014 @default.
- W2084927888 countsByYear W20849278882015 @default.
- W2084927888 countsByYear W20849278882016 @default.
- W2084927888 countsByYear W20849278882017 @default.
- W2084927888 countsByYear W20849278882018 @default.
- W2084927888 countsByYear W20849278882019 @default.
- W2084927888 countsByYear W20849278882020 @default.
- W2084927888 countsByYear W20849278882021 @default.
- W2084927888 countsByYear W20849278882022 @default.
- W2084927888 crossrefType "journal-article" @default.
- W2084927888 hasAuthorship W2084927888A5003540685 @default.
- W2084927888 hasAuthorship W2084927888A5023471727 @default.
- W2084927888 hasAuthorship W2084927888A5055337379 @default.
- W2084927888 hasAuthorship W2084927888A5076990895 @default.
- W2084927888 hasAuthorship W2084927888A5081542680 @default.
- W2084927888 hasConcept C2776021129 @default.
- W2084927888 hasConcept C2776520383 @default.
- W2084927888 hasConcept C2777027569 @default.
- W2084927888 hasConcept C2777949923 @default.
- W2084927888 hasConcept C2778651397 @default.
- W2084927888 hasConcept C2778897966 @default.
- W2084927888 hasConcept C2778980435 @default.
- W2084927888 hasConcept C2779489039 @default.
- W2084927888 hasConcept C501593827 @default.
- W2084927888 hasConcept C523546767 @default.
- W2084927888 hasConcept C54355233 @default.
- W2084927888 hasConcept C58123911 @default.
- W2084927888 hasConcept C71924100 @default.
- W2084927888 hasConcept C86803240 @default.
- W2084927888 hasConcept C89423630 @default.
- W2084927888 hasConceptScore W2084927888C2776021129 @default.
- W2084927888 hasConceptScore W2084927888C2776520383 @default.
- W2084927888 hasConceptScore W2084927888C2777027569 @default.
- W2084927888 hasConceptScore W2084927888C2777949923 @default.
- W2084927888 hasConceptScore W2084927888C2778651397 @default.
- W2084927888 hasConceptScore W2084927888C2778897966 @default.
- W2084927888 hasConceptScore W2084927888C2778980435 @default.
- W2084927888 hasConceptScore W2084927888C2779489039 @default.
- W2084927888 hasConceptScore W2084927888C501593827 @default.
- W2084927888 hasConceptScore W2084927888C523546767 @default.
- W2084927888 hasConceptScore W2084927888C54355233 @default.
- W2084927888 hasConceptScore W2084927888C58123911 @default.
- W2084927888 hasConceptScore W2084927888C71924100 @default.
- W2084927888 hasConceptScore W2084927888C86803240 @default.
- W2084927888 hasConceptScore W2084927888C89423630 @default.
- W2084927888 hasIssue "10" @default.
- W2084927888 hasLocation W20849278881 @default.
- W2084927888 hasLocation W20849278882 @default.
- W2084927888 hasOpenAccess W2084927888 @default.
- W2084927888 hasPrimaryLocation W20849278881 @default.
- W2084927888 hasRelatedWork W1905861186 @default.
- W2084927888 hasRelatedWork W1982636754 @default.
- W2084927888 hasRelatedWork W1983362375 @default.
- W2084927888 hasRelatedWork W1994288441 @default.
- W2084927888 hasRelatedWork W2057380905 @default.
- W2084927888 hasRelatedWork W2084927888 @default.
- W2084927888 hasRelatedWork W2112822838 @default.
- W2084927888 hasRelatedWork W2150371194 @default.
- W2084927888 hasRelatedWork W2317035879 @default.
- W2084927888 hasRelatedWork W2403691780 @default.
- W2084927888 hasVolume "27" @default.
- W2084927888 isParatext "false" @default.
- W2084927888 isRetracted "false" @default.
- W2084927888 magId "2084927888" @default.