Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084947347> ?p ?o ?g. }
- W2084947347 endingPage "241" @default.
- W2084947347 startingPage "234" @default.
- W2084947347 abstract "Toll-like receptors (TLRs) are a critical component of the innate immune response in many vertebrates, including avian species. The recent findings of chicken TLRs (cTLRs) expression in ovarian follicles and in the chicken ovary in vivo, as well as the changes in their expression in response to lipopolysaccharide or Salmonella enteritidis (SE) infection, have broad implications for reproductive physiology and for the prevention of transmission of zoonotic diseases to humans through the consumption of contaminated poultry eggs. Because the main route of egg contamination is from infection of the oviduct and mainly from the vagina, the aim of this study was to investigate the expression of the ten cTLRs identified to date in the chicken oviduct in vivo, to determine whether sexual maturation affects their mRNA abundance and to investigate whether SE infection alters the expression of TLRs in the chicken vagina. RNA was extracted from the vagina of healthy prepubertal, sexually mature and aged birds, and from sexually mature and aged SE infected birds. RT-PCR analysis revealed that all types of cTLRs apart from TLR1-1 were expressed in the vagina of sexually mature birds. Quantitative real-time PCR analysis revealed that the mRNA abundance of TLR2-1, 2-2 and 4 differ with respect to sexual maturation in the chicken vagina. SE infection resulted in a significant induction of TLR5 and 15 in the vagina of sexually mature birds, and in a significant induction of TLR2-1, 4 and 15 in the vagina of aged birds, while a significant down-regulation was observed for TLR7 in the vagina of sexually mature birds. These findings suggest that a TLR mediated immune response mechanism exists in the chicken vagina, playing a crucial role in preventing microbial pathogens from being incorporated into newly forming eggs." @default.
- W2084947347 created "2016-06-24" @default.
- W2084947347 creator A5010874395 @default.
- W2084947347 creator A5017992736 @default.
- W2084947347 creator A5047678710 @default.
- W2084947347 date "2011-02-01" @default.
- W2084947347 modified "2023-09-26" @default.
- W2084947347 title "Effects of sexual maturation and Salmonella infection on the expression of Toll-like receptors in the chicken vagina" @default.
- W2084947347 cites W1655860314 @default.
- W2084947347 cites W1963937775 @default.
- W2084947347 cites W1979218859 @default.
- W2084947347 cites W1983558967 @default.
- W2084947347 cites W1987785017 @default.
- W2084947347 cites W1988598225 @default.
- W2084947347 cites W1990149357 @default.
- W2084947347 cites W1991872651 @default.
- W2084947347 cites W1993643855 @default.
- W2084947347 cites W2000192473 @default.
- W2084947347 cites W2008428468 @default.
- W2084947347 cites W2008914561 @default.
- W2084947347 cites W2010967002 @default.
- W2084947347 cites W2015524285 @default.
- W2084947347 cites W2029408534 @default.
- W2084947347 cites W2031863722 @default.
- W2084947347 cites W2046435095 @default.
- W2084947347 cites W2046468933 @default.
- W2084947347 cites W2049163942 @default.
- W2084947347 cites W2053971578 @default.
- W2084947347 cites W2074689059 @default.
- W2084947347 cites W2077645766 @default.
- W2084947347 cites W2080182957 @default.
- W2084947347 cites W2081222766 @default.
- W2084947347 cites W2091398245 @default.
- W2084947347 cites W2107277218 @default.
- W2084947347 cites W2114048032 @default.
- W2084947347 cites W2114570899 @default.
- W2084947347 cites W2121552559 @default.
- W2084947347 cites W2123835388 @default.
- W2084947347 cites W2127459392 @default.
- W2084947347 cites W2132190124 @default.
- W2084947347 cites W2139437936 @default.
- W2084947347 cites W2142241097 @default.
- W2084947347 cites W2143135577 @default.
- W2084947347 cites W2152536923 @default.
- W2084947347 cites W2155697606 @default.
- W2084947347 cites W2157339124 @default.
- W2084947347 cites W2162899229 @default.
- W2084947347 cites W2413899026 @default.
- W2084947347 doi "https://doi.org/10.1016/j.anireprosci.2011.01.010" @default.
- W2084947347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21292412" @default.
- W2084947347 hasPublicationYear "2011" @default.
- W2084947347 type Work @default.
- W2084947347 sameAs 2084947347 @default.
- W2084947347 citedByCount "27" @default.
- W2084947347 countsByYear W20849473472012 @default.
- W2084947347 countsByYear W20849473472013 @default.
- W2084947347 countsByYear W20849473472014 @default.
- W2084947347 countsByYear W20849473472015 @default.
- W2084947347 countsByYear W20849473472016 @default.
- W2084947347 countsByYear W20849473472017 @default.
- W2084947347 countsByYear W20849473472019 @default.
- W2084947347 countsByYear W20849473472022 @default.
- W2084947347 countsByYear W20849473472023 @default.
- W2084947347 crossrefType "journal-article" @default.
- W2084947347 hasAuthorship W2084947347A5010874395 @default.
- W2084947347 hasAuthorship W2084947347A5017992736 @default.
- W2084947347 hasAuthorship W2084947347A5047678710 @default.
- W2084947347 hasConcept C105702510 @default.
- W2084947347 hasConcept C134018914 @default.
- W2084947347 hasConcept C136449434 @default.
- W2084947347 hasConcept C203014093 @default.
- W2084947347 hasConcept C2777129507 @default.
- W2084947347 hasConcept C2777744392 @default.
- W2084947347 hasConcept C2781236682 @default.
- W2084947347 hasConcept C42407357 @default.
- W2084947347 hasConcept C86803240 @default.
- W2084947347 hasConcept C8891405 @default.
- W2084947347 hasConcept C89423630 @default.
- W2084947347 hasConceptScore W2084947347C105702510 @default.
- W2084947347 hasConceptScore W2084947347C134018914 @default.
- W2084947347 hasConceptScore W2084947347C136449434 @default.
- W2084947347 hasConceptScore W2084947347C203014093 @default.
- W2084947347 hasConceptScore W2084947347C2777129507 @default.
- W2084947347 hasConceptScore W2084947347C2777744392 @default.
- W2084947347 hasConceptScore W2084947347C2781236682 @default.
- W2084947347 hasConceptScore W2084947347C42407357 @default.
- W2084947347 hasConceptScore W2084947347C86803240 @default.
- W2084947347 hasConceptScore W2084947347C8891405 @default.
- W2084947347 hasConceptScore W2084947347C89423630 @default.
- W2084947347 hasIssue "3-4" @default.
- W2084947347 hasLocation W20849473471 @default.
- W2084947347 hasLocation W20849473472 @default.
- W2084947347 hasOpenAccess W2084947347 @default.
- W2084947347 hasPrimaryLocation W20849473471 @default.
- W2084947347 hasRelatedWork W1578468597 @default.
- W2084947347 hasRelatedWork W1914689199 @default.
- W2084947347 hasRelatedWork W1921112241 @default.
- W2084947347 hasRelatedWork W1981462882 @default.