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- W2084950460 abstract "Since the identification of Catechol-O-Methyltransferase (COMT) by Axelrod in 1957, many inhibitors of this enzyme have been reported. While COMT inhibition may be beneficial in a number of disease states, most of the effort over the years has been directed at boosting L-DOPA concentrations as adjunct treatment for Parkinson’s disease. This review summarizes the major classes of COMT inhibitors, from early catechol and pyrogallol variants to bisubstrate inhibitors. The nitrocatechol substructure has proven to be a particularly productive scaffold, resulting in two marketed drugs and several improved drug candidates working their way through clinical trials. Keywords: Catechol-O-methyltransferase, COMT, dopamine, L-DOPA, Parkinson's disease, nitrocatechol, MB-COMT, SAM Binding, HPLC, DOPAC" @default.
- W2084950460 created "2016-06-24" @default.
- W2084950460 creator A5074794226 @default.
- W2084950460 date "2012-05-01" @default.
- W2084950460 modified "2023-10-01" @default.
- W2084950460 title "Inhibitors of Catechol-O-Methyltransferase" @default.
- W2084950460 doi "https://doi.org/10.2174/187152712800672517" @default.
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